Linked Life Data

17503042

Source:http://linkedlifedata.com/resource/pubmed/id/17503042

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-8-27
pubmed:abstractText
The precise molecular targets of interferon-alpha (IFN-alpha) therapy of melanoma are unknown but likely involve signal transducer and activator of transcription 1 (STAT1) signal transduction within host immune effector cells. We hypothesized that microarray analysis could be utilized to identify candidate molecular targets important for mediating the anti-tumor effect of exogenously administered IFN-alpha. EXPERIMENTAL METHODS: To identify the STAT1-dependent genes regulated by IFN-alpha, the gene expression profile of splenocytes from wild type (WT) and STAT1(-/-) mice was characterized.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0340-7004
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1845-52
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
STAT1-dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha.
pubmed:affiliation
Integrated Biological Sciences Graduate Program, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural