| pubmed-article:17499751 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17499751 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17499751 | lifeskim:mentions | umls-concept:C0006255 | lld:lifeskim |
| pubmed-article:17499751 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17499751 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:17499751 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:17499751 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17499751 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17499751 | pubmed:dateCreated | 2007-5-14 | lld:pubmed |
| pubmed-article:17499751 | pubmed:abstractText | The present study investigated the ability of 5-oxo-EicosaTetraEnoic acid (5-oxo-ETE) for modulating airway smooth muscle (ASM) tone in human bronchi. 5-Oxo-ETE induced a concentration-dependent relaxing effect on human bronchi pre-contracted with methacholine (MCh) and arachidonic acid (AA). This relaxing response was highly sensitive to Iberiotoxin (IbTx), a large conducting Ca(2+)-activated K(+) channel (BK(Ca)) inhibitor. Furthermore, microelectrode measurements revealed that 5-oxo-ETE (0.1-10 microM) hyperpolarizes the membrane potential of human bronchial ASM cells. These hyperpolarizing effects were also inhibited in the presence of 10nM IbTx. Lastly, 5-oxo-ETE was shown to directly activate reconstituted BK(Ca) channels derived from human airway smooth muscles. In summary, the 5-oxo-ETE eicosanoid activates a specific K(+) conductance, involved in membrane hyperpolarization, which in turn reduces Ca(2+) entry and facilitates relaxation of smooth muscle cells. | lld:pubmed |
| pubmed-article:17499751 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17499751 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17499751 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17499751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17499751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17499751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17499751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17499751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17499751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17499751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17499751 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17499751 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17499751 | pubmed:issn | 1098-8823 | lld:pubmed |
| pubmed-article:17499751 | pubmed:author | pubmed-author:RousseauEricE | lld:pubmed |
| pubmed-article:17499751 | pubmed:author | pubmed-author:MorinCaroline... | lld:pubmed |
| pubmed-article:17499751 | pubmed:author | pubmed-author:SiroisMarcoM | lld:pubmed |
| pubmed-article:17499751 | pubmed:author | pubmed-author:EchaveVincent... | lld:pubmed |
| pubmed-article:17499751 | pubmed:author | pubmed-author:GomesMarcio... | lld:pubmed |
| pubmed-article:17499751 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17499751 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:17499751 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17499751 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17499751 | pubmed:pagination | 311-9 | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:meshHeading | pubmed-meshheading:17499751... | lld:pubmed |
| pubmed-article:17499751 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17499751 | pubmed:articleTitle | Relaxing effects of 5-oxo-ETE on human bronchi involve BK Ca channel activation. | lld:pubmed |
| pubmed-article:17499751 | pubmed:affiliation | Le Bilarium, Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Université de Sherbrooke 3001, 12th Avenue North, Sherbrooke J1H 5N4, Que., Canada. | lld:pubmed |
| pubmed-article:17499751 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17499751 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:17499751 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17499751 | lld:pubmed |
