Linked Life Data

17495542

Source:http://linkedlifedata.com/resource/pubmed/id/17495542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2007-5-29
pubmed:abstractText
It is imperative that quiescent Saccharomyces cerevisiae cells respond rapidly to fresh medium: the cell that initiates growth and division soonest has the most progeny. Several laboratories have used DNA microarrays to identify transcripts that are altered when fresh medium is added to quiescent cells. We combined published data with our own to address several questions: Do these experiments taken together identify a core set of genes that is reproducibly affected when quiescent cells are stimulated by nutrient repletion? Is this gene set coregulated in response to other environmental challenges? Does promoter histone occupancy correlate with the mRNA data? Despite diverse experimental designs, the data were highly correlated, generating a set of nutrient repletion transcripts. Glucose addition accounted for the response. These transcripts were also coregulated in response to diverse stresses. Promoters were associated with increased histone acetylation and decreased histone occupancy when induced, and high histone occupancy with low acetylation when repressed. The presence of RRPE and PAC promoter elements correlated with nutrient responsiveness and a dynamic pattern of histone occupancy and acetylation. Correlative evidence supports the idea that some mRNAs may be upregulated by release from sequestration in RNA-protein complexes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1551-4005
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1210-9
pubmed:dateRevised
2008-9-23
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Coordinated regulation of growth genes in Saccharomyces cerevisiae.
pubmed:affiliation
Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't