Source:http://linkedlifedata.com/resource/pubmed/id/17494887
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
2007-5-28
|
pubmed:abstractText |
For defining the pathogenic effects of the (pro)renin receptor-transgenic rat, strains that overexpressed the human receptor were generated. Although transgenic rats were normotensive and euglycemic and had a renal angiotensin II (AngII) level that was comparable to that of wild-type rats, transgenic rats developed proteinuria with aging and significant glomerulosclerosis at 28 wk of age. In kidneys of 28-wk-old transgenic rats, mitogen-activated protein kinases (MAPK) were activated without recognizable tyrosine phosphorylation of the EGF receptor, and expression of TGF-beta1 was enhanced. In vivo infusion of the (pro)renin receptor blocker peptide (formerly handle region decoy peptide) significantly inhibited the development of glomerulosclerosis, proteinuria, MAPK activation, and TGF-beta1 expression in the kidneys, but the angiotensin-converting enzyme inhibitor did not attenuate these changes despite a significant decrease in the renal AngII level. In addition, recombinant rat prorenin stimulated MAPK activation in the human receptor-expressed cultured cells, but human receptor was unable to evoke the enzyme activity of rat prorenin. Thus, human (pro)renin receptor elicits slowly progressive nephropathy by AngII-independent MAPK activation in rats. This study clearly provided in vivo evidence for the AngII-independent MAPK activation by human (pro)renin receptor and induction of glomerulosclerosis with increased TGF-beta1 expression.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin I,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/prorenin receptor
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1046-6673
|
pubmed:author |
pubmed-author:IchiharaAtsuhiroA,
pubmed-author:InagamiTadashiT,
pubmed-author:ItohHiroshiH,
pubmed-author:KaneshiroYukiY,
pubmed-author:NabiA H M NurunAH,
pubmed-author:NakagawaTsutomuT,
pubmed-author:NishiyamaAkiraA,
pubmed-author:SakodaMariyoM,
pubmed-author:SuzukiFumiakiF,
pubmed-author:TakemitsuTomokoT,
pubmed-author:UddinM NasirMN
|
pubmed:issnType |
Print
|
pubmed:volume |
18
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1789-95
|
pubmed:meshHeading |
pubmed-meshheading:17494887-Age Factors,
pubmed-meshheading:17494887-Angiotensin I,
pubmed-meshheading:17494887-Angiotensin II,
pubmed-meshheading:17494887-Animals,
pubmed-meshheading:17494887-Animals, Genetically Modified,
pubmed-meshheading:17494887-COS Cells,
pubmed-meshheading:17494887-Cercopithecus aethiops,
pubmed-meshheading:17494887-Disease Progression,
pubmed-meshheading:17494887-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:17494887-Humans,
pubmed-meshheading:17494887-MAP Kinase Signaling System,
pubmed-meshheading:17494887-Proteinuria,
pubmed-meshheading:17494887-Rats,
pubmed-meshheading:17494887-Receptors, Cell Surface,
pubmed-meshheading:17494887-Transforming Growth Factor beta1
|
pubmed:year |
2007
|
pubmed:articleTitle |
Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats.
|
pubmed:affiliation |
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|