Linked Life Data

17489732

Source:http://linkedlifedata.com/resource/pubmed/id/17489732

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-5-10
pubmed:abstractText
Systems biology attempts to elucidate the complex interaction between genes, proteins and metabolites to provide a mechanistic understanding of cellular function and how this function is affected by disease processes, drug toxicity or drug efficacy effects. Global metabolic profiling is an important component of systems biology that can be applied in both preclinical and clinical settings for drug discovery and development, and to study disease mechanisms. The metabolic profile encodes the phenotype, which is composed of the genotype and environmental factors. The phenotypic profile can be used to make decisions about the best course of treatment for an individual patient. Understanding the combined effects of genetics and environment through a systems biology framework will enable the advancement of personalized medicine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1744-8352
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-59
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Global metabolic profiling and its role in systems biology to advance personalized medicine in the 21st century.
pubmed:affiliation
National Center for Toxicological Research, Division of Systems Toxicology, US Food & Drug Administration, Jefferson, AR 72079-9502, USA. laura.schnackenberg@fda.hhs.gov
pubmed:publicationType
Journal Article, Review