Source:http://linkedlifedata.com/resource/pubmed/id/17489364
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2007-5-10
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pubmed:abstractText |
A novel proteinase fraction, SPP-501, was purified from the earthworm, Eisenia andrei, and its antithrombotic effects compared with those of urokinase and t-PA (tissue type-plasminogen activator) in a thrombosis model, induced by the insertion of a stainless wire coil into the inferior vena cava. SPP-501, urokinase and t-PA were administrated once a day for 14 days. On the oral administration of SPP-501, as well as urokinase and t-PA, the thrombus weight was dramatically decreased. The euglobulin lysis time (ELT) was also shortened by SPP-501, but urokinase and t-PA failed to dissolve the euglobulin clot. Conversely, urokinase and t-PA produced detectable fibrinogen/fibrin degradation products (FDP), but SPP-501 did not. Thrombin induced platelet aggregation was desensitized in the SPP-501 treatment groups. With a high dose of SPP-501 (45 mg/kg), the APTT (activated partial thromboplastin time) was prolonged. These results suggest that SPP-501 shows both antithrombotic and fibrinolytic activities when orally administered.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0253-6269
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
475-80
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pubmed:meshHeading |
pubmed-meshheading:17489364-Administration, Oral,
pubmed-meshheading:17489364-Animals,
pubmed-meshheading:17489364-Fibrinolysis,
pubmed-meshheading:17489364-Fibrinolytic Agents,
pubmed-meshheading:17489364-Male,
pubmed-meshheading:17489364-Oligochaeta,
pubmed-meshheading:17489364-Peptide Hydrolases,
pubmed-meshheading:17489364-Platelet Aggregation,
pubmed-meshheading:17489364-Rats,
pubmed-meshheading:17489364-Rats, Sprague-Dawley,
pubmed-meshheading:17489364-Venous Thrombosis,
pubmed-meshheading:17489364-Whole Blood Coagulation Time
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pubmed:year |
2007
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pubmed:articleTitle |
Antithrombotic effects by oral administration of novel proteinase fraction from earthworm Eisenia andrei on venous thrombosis model in rats.
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pubmed:affiliation |
Central Research Institute, Shin Poong Pharm. Co. Ltd., Ansan, Korea. cklee@shinpoong.co.kr
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pubmed:publicationType |
Journal Article
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