Linked Life Data

17485366

Source:http://linkedlifedata.com/resource/pubmed/id/17485366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-5-8
pubmed:abstractText
Corin is a type II transmembrane serine protease expressed primarily in the heart. Functional studies have shown that corin converts pro-atrial natriuretic peptide (pro-ANP) to mature ANP, a cardiac hormone important in regulating salt-water balance and maintaining normal blood pressure. In corin-deficient mice, pro-ANP processing is abolished, demonstrating that corin is the physiological pro-ANP convertase. Corin-deficient mice develop hypertension that is exacerbated by a high-salt diet and during pregnancy, indicating the importance of this enzyme in controlling blood pressure. More recently, single nucleotide polymorphisms (SNPs) are found in the human corin gene, which are associated with an increased risk for hypertension and cardiac hypertrophy. This review describes the biology of corin and its potential role in cardiovascular disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4179-90
pubmed:dateRevised
2010-6-4
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The serine protease corin in cardiovascular biology and disease.
pubmed:affiliation
Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. wuq@ccf.org
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't