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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
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|
pubmed:dateCreated |
2007-7-30
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|
pubmed:abstractText |
To investigate whether differences in plasma pharmacokinetic profiles of gefitinib between healthy subjects having normal (N; t(1/2)>20h) and altered (A; t(1/2)<20h) pharmacokinetic (PK) profiles might be explained by inter-individual variability in gastric emptying and/or precipitation/dissolution of gefitinib in the proximal small intestine.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Aug
|
|
pubmed:issn |
0378-5173
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
16
|
|
pubmed:volume |
341
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
134-42
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17482782-Administration, Oral,
pubmed-meshheading:17482782-Adult,
pubmed-meshheading:17482782-Antineoplastic Agents,
pubmed-meshheading:17482782-Chemical Precipitation,
pubmed-meshheading:17482782-Crystallization,
pubmed-meshheading:17482782-Gastric Emptying,
pubmed-meshheading:17482782-Half-Life,
pubmed-meshheading:17482782-Humans,
pubmed-meshheading:17482782-Intestinal Secretions,
pubmed-meshheading:17482782-Intubation, Gastrointestinal,
pubmed-meshheading:17482782-Jejunum,
pubmed-meshheading:17482782-Male,
pubmed-meshheading:17482782-Microscopy,
pubmed-meshheading:17482782-Middle Aged,
pubmed-meshheading:17482782-Protein Kinase Inhibitors,
pubmed-meshheading:17482782-Quinazolines,
pubmed-meshheading:17482782-Reference Values,
pubmed-meshheading:17482782-Solubility,
pubmed-meshheading:17482782-Spectrum Analysis, Raman
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Pharmacokinetics of gefitinib in humans: the influence of gastrointestinal factors.
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|
pubmed:affiliation |
Department of Pharmacy, Uppsala University, Box 580, 751 23 Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
|
