Linked Life Data

17474118

Source:http://linkedlifedata.com/resource/pubmed/id/17474118

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pubmed-article:17474118pubmed:dateCreated2007-5-22lld:pubmed
pubmed-article:17474118pubmed:abstractTextNuclear beta-catenin plays crucial roles in the establishment of the embryonic axis and formation of mesendoderm tissues in ascidians and other animals. However, the cue responsible for nuclear accumulation of beta-catenin in the vegetal hemisphere is still unknown in ascidians. Here, we investigated the roles of Wnt5alpha and Dsh in the nuclear accumulation of beta-catenin and activation of its downstream genes in the ascidian Halocynthia roretzi. Wnt5alpha knockdown embryos lost nuclear accumulation of beta-catenin at the 64-cell stage but not at the 32-cell stage, and expression of Hr-lim, one of the targets of beta-catenin, was impaired in the anterior region of the embryo. Zygotic Wnt5alpha expression in the anterior-vegetal blastomeres was primarily responsible for these defects. Dsh knockdown showed no effect on nuclear localization of beta-catenin, but inhibited Hr-lim expression in the posterior region. These results suggest that maintenance of nuclear Hr-beta-catenin after the 64-cell stage is regulated by zygotic Hr-Wnt5alpha, and that expression of its target genes is modulated by both Hr-Wnt5alpha and Hr-Dsh. Our results also highlight the importance of nuclear accumulation of beta-catenin up to the 32-cell stage through a still unclarified mechanism.lld:pubmed
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pubmed-article:17474118pubmed:authorpubmed-author:NishidaHiroki...lld:pubmed
pubmed-article:17474118pubmed:authorpubmed-author:KumanoGakuGlld:pubmed
pubmed-article:17474118pubmed:authorpubmed-author:KawaiNarudoNlld:pubmed
pubmed-article:17474118pubmed:authorpubmed-author:IidaYoheiYlld:pubmed
pubmed-article:17474118pubmed:copyrightInfoCopyright 2007 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:17474118pubmed:volume236lld:pubmed
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pubmed-article:17474118pubmed:pagination1570-82lld:pubmed
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pubmed-article:17474118pubmed:year2007lld:pubmed
pubmed-article:17474118pubmed:articleTitleNuclear accumulation of beta-catenin and transcription of downstream genes are regulated by zygotic Wnt5alpha and maternal Dsh in ascidian embryos.lld:pubmed
pubmed-article:17474118pubmed:affiliationDepartment of Biological Sciences, Graduate School of Sciences, Osaka University, Osaka, Japan. narudo.kawai@obs-vlfr.frlld:pubmed
pubmed-article:17474118pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17474118pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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