Source:http://linkedlifedata.com/resource/pubmed/id/17464276
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2007-10-9
|
| pubmed:abstractText |
Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by a cellular-mediated immune response driven by cytokines secreted mainly by T helper 1 cells (Th1). In active phases of the disease, an increased production and release of tumor necrosis factor a (TNFalpha) by macrophages and monocytes of the lamina propria has been described. The aim of this study was to detect the presence of TNFalpha within the gut mucosa in patients with active CD by using (99m)Tc-labelled chimeric human/mouse monoclonal antibody anti-TNFalpha (Infliximab, Remicade).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1824-4785
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
334-42
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| pubmed:meshHeading |
pubmed-meshheading:17464276-Animals,
pubmed-meshheading:17464276-Antibodies, Monoclonal,
pubmed-meshheading:17464276-Cells, Cultured,
pubmed-meshheading:17464276-Crohn Disease,
pubmed-meshheading:17464276-Humans,
pubmed-meshheading:17464276-Lymphocytes,
pubmed-meshheading:17464276-Mice,
pubmed-meshheading:17464276-Organ Specificity,
pubmed-meshheading:17464276-Radiopharmaceuticals,
pubmed-meshheading:17464276-Technetium,
pubmed-meshheading:17464276-Tissue Distribution,
pubmed-meshheading:17464276-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Use of a 99mTc labeled anti-TNFalpha monoclonal antibody in Crohn's disease: in vitro and in vivo studies.
|
| pubmed:affiliation |
Nuclear Medicine Unit, II Faculty of Medicine, La Sapienza University of Rome, Rome, Italy.
|
| pubmed:publicationType |
Journal Article
|