Source:http://linkedlifedata.com/resource/pubmed/id/17462514
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2007-4-27
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| pubmed:abstractText |
The clinical course and outcome of human immunodeficiency virus-1 (HIV-1) infection are highly variable among individuals. CCR5 is the primary coreceptor that mediates entry of HIV-1 (R5) into permissive host cells. In this study, five SNPs (59029G/A, 59353T/C, 59356C/T, 59402A/G, and 59653C/T) in the promoter region and a deletion of 32 bp (Delta32) in the CCR5 gene were evaluated in 180 chronically HIV-1-infected North Indians. The study showed the following: (1) the protective CCR5 Delta32 allele was absent; (2) the frequency of CCR5*59402A allele in the HIV-infected people (66.4%) was higher than in healthy subjects (57.1%, p = 0.027) and in the CDC stage C patients (76%) versus stages A and B patients together (60%; p = 0.002); (3) homozygous CCR5*59402 AA genotype was significantly increased in the seropositive subjects (46.1%) compared with healthy control subjects (30.2%; p = 0.008) and in the CDC stage C patients (59.2%) compared with stage A and B subjects (37.6%, p = 0.007); and (4) an increased frequency of homozygous ACCAC haplotype was present in the seropositive stage C patients (32.4%) versus 15.6% in patients in stages A plus B (p = 0.013). These observations suggest an association of CCR5*59402A with increased likelihood of acquisition of HIV-1 and development of AIDS in the Asian Indian population. Further studies are required to confirm these findings and understand the effect of CCR5 polymorphisms on the outcome of HIV-1 infection.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0198-8859
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
68
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
454-61
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17462514-Adolescent,
pubmed-meshheading:17462514-Adult,
pubmed-meshheading:17462514-Aged,
pubmed-meshheading:17462514-CD4 Lymphocyte Count,
pubmed-meshheading:17462514-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17462514-Child,
pubmed-meshheading:17462514-Child, Preschool,
pubmed-meshheading:17462514-Gene Deletion,
pubmed-meshheading:17462514-Gene Frequency,
pubmed-meshheading:17462514-Genotype,
pubmed-meshheading:17462514-HIV Infections,
pubmed-meshheading:17462514-HIV Seropositivity,
pubmed-meshheading:17462514-HIV-1,
pubmed-meshheading:17462514-Haplotypes,
pubmed-meshheading:17462514-Humans,
pubmed-meshheading:17462514-India,
pubmed-meshheading:17462514-Lymphocyte Count,
pubmed-meshheading:17462514-Middle Aged,
pubmed-meshheading:17462514-Polymorphism, Genetic,
pubmed-meshheading:17462514-Polymorphism, Single Nucleotide,
pubmed-meshheading:17462514-Promoter Regions, Genetic,
pubmed-meshheading:17462514-Receptors, CCR5
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Polymorphism in the CCR5 gene promoter and HIV-1 infection in North Indians.
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| pubmed:affiliation |
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|