Linked Life Data

17459415

Source:http://linkedlifedata.com/resource/pubmed/id/17459415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2008-1-15
pubmed:abstractText
Autoreactive T and B cells are regular components of the healthy immune system. It has been proposed that some of these cells might have a protective function. Recent studies support this notion by demonstrating that a) myelin-autoreactive T cells show neuroprotective effects in vivo, and b) activated antigen-specific human T cells and other immune cells produce bioactive brain-derived neurotrophic factor (BDNF) and other neurotrophic factors in vitro. Furthermore, neurotrophic factors are expressed in different types of inflammatory cells in brain lesions of patients with acute disseminated leukoencephalopathy or multiple sclerosis. It seems plausible that the immune cell-mediated import of neurotrophic factors into the central nervous system has functional consequences, with obvious implications for the therapy of multiple sclerosis and other neuroimmunological diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
265
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-6
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Neurotrophic cross-talk between the nervous and immune systems: relevance for repair strategies in multiple sclerosis?
pubmed:affiliation
Institute of Clinical Neuroimmunology, Campus Grosshadern, Ludwig-Maximilians University, Marchioninistr, 15, D-81366 Munich, Germany. hohlfeld@neuro.mpg.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't