Source:http://linkedlifedata.com/resource/pubmed/id/17457134
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2007-4-25
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pubmed:abstractText |
Prostaglandins play a major role in inflammation and pain. They are synthesized by the two cyclooxygenase (COX) isoforms: COX-1, which is expressed constitutively in many cell types, and COX-2, which is induced at the site of inflammation. However, unlike peripheral tissues, COX-2 is expressed constitutively in the central nervous system and may play a role in nociceptive processes. The current study aimed to investigate the role of constitutive COX-2 in the spinal transmission of nociceptive signals in humans.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0003-3022
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1013-8
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pubmed:meshHeading |
pubmed-meshheading:17457134-Adult,
pubmed-meshheading:17457134-Cross-Over Studies,
pubmed-meshheading:17457134-Cyclooxygenase 2,
pubmed-meshheading:17457134-Double-Blind Method,
pubmed-meshheading:17457134-Female,
pubmed-meshheading:17457134-Humans,
pubmed-meshheading:17457134-Isoxazoles,
pubmed-meshheading:17457134-Male,
pubmed-meshheading:17457134-Pain,
pubmed-meshheading:17457134-Pain Threshold,
pubmed-meshheading:17457134-Reflex,
pubmed-meshheading:17457134-Spinal Cord
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pubmed:year |
2007
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pubmed:articleTitle |
Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale (INSERM) U-792, Centre Hospitalier Universitaire Ambroise Paré, Centre d'Evaluation et de Traitement de la Douleur, Assistance Publique - Hôpitaux de Paris (AP-HP), Boulogne-Billancourt, France.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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