Linked Life Data

17448450

Source:http://linkedlifedata.com/resource/pubmed/id/17448450

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-5-29
pubmed:abstractText
The influence of emotion on cognition plays an important role in people's everyday life as well as in psychiatric and neurological disorders. The present study used fMRI to examine the neural correlates of cognitive-emotional interactions and its inter-individual differences. Twenty-one healthy males performed a 0-back/2-back task while negative or neutral emotion was induced by negative/neutral olfactory stimulation. Subjects revealed a differential effect of emotion on cognition; in 9 subjects, negative odor had a deteriorating influence on verbal working memory ("affected group", AG) while in 12 subjects, performance was not affected in a negative way ("unaffected group", UAG). Although no brain activation differences emerged during the working memory task, the interaction of working memory and emotion yielded significant differences between the AG and the UAG. The latter showed greater activation in the fronto-parieto-cerebellar working memory (WM) network including the precuneus while the AG demonstrated stronger activation in more "emotional" areas (mainly the temporal and medial frontal cortex) as well as compensatory activations in prefrontal regions known to be essential for the cognitive down-regulation of emotions. Hence, the UAG may have been better able to counteract the detrimental influence of negative stimulation during the 2-back task and to effectively sustain or even increase activation in the task-relevant WM network. Correlation analyses for the whole group supported this interpretation; reduced working memory performance during negative stimulation was accompanied by higher activation in the inferior frontal gyrus whereas less performance impairment was related to higher activation in the precuneus. Results confirm the importance of incorporating individual differences in emotion processing and its interaction with cognitive functions in neuroimaging.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
1152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-70
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The influence of olfactory-induced negative emotion on verbal working memory: individual differences in neurobehavioral findings.
pubmed:affiliation
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany. uhabel@ukaachen.de <uhabel@ukaachen.de>
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't