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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2007-5-7
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pubmed:abstractText |
The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-10381577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-10498270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-11165488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-11394996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-11567107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-11861160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-12574514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-12619132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-12872126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-14527269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-14586460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-14599436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-14643455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-15294144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-15452576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-15483110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-15555683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-15821730,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-16272112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-16384934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-16476668,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-16701214,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-64477,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17442747-9651520
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7652-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17442747-Animals,
pubmed-meshheading:17442747-Biological Markers,
pubmed-meshheading:17442747-Body Patterning,
pubmed-meshheading:17442747-Fibroblast Growth Factor 8,
pubmed-meshheading:17442747-Fibroblast Growth Factors,
pubmed-meshheading:17442747-Frontal Lobe,
pubmed-meshheading:17442747-Gene Expression Regulation, Developmental,
pubmed-meshheading:17442747-Mice,
pubmed-meshheading:17442747-Mice, Knockout,
pubmed-meshheading:17442747-Mutation
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pubmed:year |
2007
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pubmed:articleTitle |
Patterning of frontal cortex subdivisions by Fgf17.
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pubmed:affiliation |
Medical Scientist Training Program, University of California, San Francisco, CA 94143-2611, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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