Source:http://linkedlifedata.com/resource/pubmed/id/17439983
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 5
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| pubmed:dateCreated |
2007-5-2
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| pubmed:abstractText |
TDP-43, a nuclear factor that functions in regulating transcription and alternative splicing, was recently identified as a component of the ubiquitin-positive, tau-negative inclusions specific for frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). In the present study, we carried out immunohistochemical and biochemical analyses of brains of Guamanians with the parkinsonism-dementia complex (G-PDC) using anti-TDP-43, anti-tau and anti-ubiquitin antibodies. Immunohistochemistry with anti-TDP-43 antibodies revealed various types of positive structures in the frontotemporal and hippocampal regions of G-PDC cases. Most of these structures were negative for tau. By immunoblot analysis with the TDP-43 antibody, an abnormal 45 kDa band, as well as a diffuse staining throughout the gel, was detected in the sarkosyl-insoluble fractions of G-PDC brains. Dephosphorylation has shown that abnormal phosphorylation takes place in the accumulated TDP-43 seen in FTLD-U and ALS. These results suggest that accumulation of TDP-43 is a common process in certain neurodegenerative disorders, including FTLD-U, ALS and G-PDC.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MAPT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin,
http://linkedlifedata.com/resource/pubmed/chemical/protein TDP-43,
http://linkedlifedata.com/resource/pubmed/chemical/tau Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1460-2156
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
130
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1386-94
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| pubmed:meshHeading |
pubmed-meshheading:17439983-Adult,
pubmed-meshheading:17439983-Aged,
pubmed-meshheading:17439983-Aged, 80 and over,
pubmed-meshheading:17439983-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:17439983-Brain Chemistry,
pubmed-meshheading:17439983-Case-Control Studies,
pubmed-meshheading:17439983-DNA-Binding Proteins,
pubmed-meshheading:17439983-Female,
pubmed-meshheading:17439983-Frontal Lobe,
pubmed-meshheading:17439983-Hippocampus,
pubmed-meshheading:17439983-Humans,
pubmed-meshheading:17439983-Immunoblotting,
pubmed-meshheading:17439983-Immunohistochemistry,
pubmed-meshheading:17439983-Male,
pubmed-meshheading:17439983-Middle Aged,
pubmed-meshheading:17439983-Pick Disease of the Brain,
pubmed-meshheading:17439983-Temporal Lobe,
pubmed-meshheading:17439983-Ubiquitin,
pubmed-meshheading:17439983-tau Proteins
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| pubmed:year |
2007
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| pubmed:articleTitle |
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
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| pubmed:affiliation |
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan. masato@prit.go.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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