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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2007-5-28
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pubmed:abstractText |
The analgesic properties of cannabinoid receptor agonists are well characterized. However, numerous side effects limit the therapeutic potential of these agents. Here we report a synergistic antinociceptive interaction between the endogenous cannabinoid receptor agonist anandamide and the synthetic peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist 2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid (GW7647) in a model of acute chemical-induced pain. Moreover, we show that anandamide synergistically interacts with the large-conductance potassium channel (KCa1.1, BK) activator isopimaric acid. These findings reveal a synergistic interaction between the endocannabinoid and PPAR-alpha systems that might be exploited clinically and identify a new pharmacological effect of the BK channel activator isopimaric acid.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-11098711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-11354382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-11426841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-12237330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-14706563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-15963531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-16324422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-16373434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-16402900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-16515464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-16834756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-16997973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-17027744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-4439865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-8739213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-9685157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-9696473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17434479-9782159
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Formaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/GW 7647,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylurea Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Polyunsaturated Alkamides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cannabinoid,
http://linkedlifedata.com/resource/pubmed/chemical/anandamide
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
566
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-9
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pubmed:dateRevised |
2011-4-21
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pubmed:meshHeading |
pubmed-meshheading:17434479-Analgesics,
pubmed-meshheading:17434479-Animals,
pubmed-meshheading:17434479-Arachidonic Acids,
pubmed-meshheading:17434479-Behavior, Animal,
pubmed-meshheading:17434479-Butyric Acids,
pubmed-meshheading:17434479-Drug Synergism,
pubmed-meshheading:17434479-Formaldehyde,
pubmed-meshheading:17434479-Male,
pubmed-meshheading:17434479-Mice,
pubmed-meshheading:17434479-PPAR alpha,
pubmed-meshheading:17434479-Pain,
pubmed-meshheading:17434479-Phenylurea Compounds,
pubmed-meshheading:17434479-Polyunsaturated Alkamides,
pubmed-meshheading:17434479-Receptors, Cannabinoid
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pubmed:year |
2007
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pubmed:articleTitle |
Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647.
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pubmed:affiliation |
Department of Experimental Pharmacology, University of Naples, Naples, Italy.
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pubmed:publicationType |
Journal Article
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