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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-15
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pubmed:abstractText |
Acute respiratory distress syndrome is characterized by neutrophil accumulation in the lungs and the activation of several cytokines produced by macrophages. Olprinone hydrochloride, a specific phosphodiesterase III inhibitor, has anti-inflammatory effects and inhibits the activation of macrophages, in addition to its inotropic and vasodilatory effects. The purpose of this study was to examine the beneficial effects of olprinone on lipopolysaccharide (LPS)-induced pulmonary inflammation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1094-5539
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
166-71
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17434327-Animals,
pubmed-meshheading:17434327-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:17434327-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17434327-Cell Culture Techniques,
pubmed-meshheading:17434327-Dexamethasone,
pubmed-meshheading:17434327-Imidazoles,
pubmed-meshheading:17434327-Inflammation Mediators,
pubmed-meshheading:17434327-Lipopolysaccharides,
pubmed-meshheading:17434327-Lung,
pubmed-meshheading:17434327-Male,
pubmed-meshheading:17434327-Phosphodiesterase 3 Inhibitors,
pubmed-meshheading:17434327-Pyridones,
pubmed-meshheading:17434327-Rats,
pubmed-meshheading:17434327-Rats, Wistar,
pubmed-meshheading:17434327-Respiratory Distress Syndrome, Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Pretreatment with olprinone hydrochloride, a phosphodiesterase III inhibitor, attenuates lipopolysaccharide-induced lung injury via an anti-inflammatory effect.
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pubmed:affiliation |
Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan.
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pubmed:publicationType |
Journal Article
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