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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-7-30
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pubmed:abstractText |
The androgen receptor (AR) is a ligand-activated transcription factor that regulates numerous target genes, including prostate-specific antigen (PSA). We examined the ability of each member of the 14-3-3 family to modulate transcription of PSA through the AR. Despite significant homology within the 14-3-3 family we observed differences in the ability of each isoform to alter the transcriptional activity of the AR. Significantly, 14-3-3 sigma activated PSA-luciferase reporters not only at castrate levels of androgens, but also in the complete absence of androgens. 14-3-3 sigma also increased expression of the endogenous PSA gene in the absence of androgens. Knockdown of the AR by siRNA oligonucleotides abolished activation of these reporters by 14-3-3 sigma. These findings may have greatest significance in hormone refractory prostate cancer where the AR may be activated in a ligand-independent manner.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-10524633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-10660621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-11223178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-11266503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-11389051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-11751884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-11943742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-11987152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-12163482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-12438264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-12730237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-12775765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-14737123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-14996909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15023544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15057270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15131044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15184053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15300238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15489902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15661684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15693853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15731107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15778465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15790729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15857576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15947099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-15994976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-16278479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-16278481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-16648560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-8798343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-9010316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-9013762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-9079630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-9278512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-93747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-942051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-9865729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17433535-9927031
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/14-3-3 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Androgens,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Metribolone,
http://linkedlifedata.com/resource/pubmed/chemical/Prostate-Specific Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Androgen,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
254
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-45
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pubmed:dateRevised |
2011-6-1
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pubmed:meshHeading |
pubmed-meshheading:17433535-14-3-3 Proteins,
pubmed-meshheading:17433535-Androgens,
pubmed-meshheading:17433535-Blotting, Western,
pubmed-meshheading:17433535-Cell Line, Tumor,
pubmed-meshheading:17433535-Dose-Response Relationship, Drug,
pubmed-meshheading:17433535-Humans,
pubmed-meshheading:17433535-Luciferases,
pubmed-meshheading:17433535-Male,
pubmed-meshheading:17433535-Metribolone,
pubmed-meshheading:17433535-Prostate-Specific Antigen,
pubmed-meshheading:17433535-Prostatic Neoplasms,
pubmed-meshheading:17433535-Protein Isoforms,
pubmed-meshheading:17433535-RNA, Small Interfering,
pubmed-meshheading:17433535-Receptors, Androgen,
pubmed-meshheading:17433535-Recombinant Fusion Proteins,
pubmed-meshheading:17433535-Transcription, Genetic,
pubmed-meshheading:17433535-Transfection
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pubmed:year |
2007
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pubmed:articleTitle |
14-3-3 sigma increases the transcriptional activity of the androgen receptor in the absence of androgens.
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pubmed:affiliation |
Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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