Source:http://linkedlifedata.com/resource/pubmed/id/17414627
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2007-4-6
|
| pubmed:abstractText |
The purpose of this study was to evaluate the efficacy and safety of an epirubicin, oxaliplatin and infusional 5-fluorouracil combination in patients with advanced gastric cancer. Patients with previously untreated advanced measurable gastric cancer received epirubicin (50 mg/m2, day 1), oxaliplatin (130 mg/m2 2-h infusion, day 1) and 5-fluorouracil (750 mg/m2, 24-h infusion, day 1-3) every 3 weeks. The primary endpoint of this phase II study was the response rate according to Response Evaluation Criteria in Solid Tumors. Out of 48 patients, 46 were evaluable for efficacy and 48 for toxicity. A median of five cycles (range 1-6) was administered. The overall best response rate was 47.8% (95% confidence interval 33-63%) including 2.2% complete responses and 45.6% partial responses. The median time for progression and median overall survival was 5 (95% confidence interval 4.1-5.9) and 11 months (95% confidence interval 8.1-13.9), respectively. Grade 3/4 neutropenia and leukocytopenia were observed in 25 and 12.5% of patients, respectively. Grade 3/4 nonhematological toxicities included nausea (6.3%), vomiting (14.6%), neurological toxicity (10.4%) and mucositis (2.1%). The epirubicin, oxaliplatin and infusional 5-fluorouracil regimen was effective and well tolerated as a front-line chemotherapy for patients with metastatic or advanced gastric cancer, and should be evaluated further.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Epirubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/Organoplatinum Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/oxaliplatin
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0959-4973
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
581-6
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| pubmed:meshHeading |
pubmed-meshheading:17414627-Adult,
pubmed-meshheading:17414627-Aged,
pubmed-meshheading:17414627-Antibiotics, Antineoplastic,
pubmed-meshheading:17414627-Antimetabolites, Antineoplastic,
pubmed-meshheading:17414627-Antineoplastic Agents,
pubmed-meshheading:17414627-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17414627-Disease Progression,
pubmed-meshheading:17414627-Endpoint Determination,
pubmed-meshheading:17414627-Epirubicin,
pubmed-meshheading:17414627-Female,
pubmed-meshheading:17414627-Fluorouracil,
pubmed-meshheading:17414627-Follow-Up Studies,
pubmed-meshheading:17414627-Humans,
pubmed-meshheading:17414627-Infusions, Intravenous,
pubmed-meshheading:17414627-Male,
pubmed-meshheading:17414627-Middle Aged,
pubmed-meshheading:17414627-Neoplasm Metastasis,
pubmed-meshheading:17414627-Organoplatinum Compounds,
pubmed-meshheading:17414627-Stomach Neoplasms,
pubmed-meshheading:17414627-Survival Analysis
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Phase II study of epirubicin plus oxaliplatin and infusional 5-fluorouracil as first-line combination therapy in patients with metastatic or advanced gastric cancer.
|
| pubmed:affiliation |
Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PRC.
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| pubmed:publicationType |
Journal Article,
Clinical Trial, Phase II
|