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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-4-6
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pubmed:abstractText |
Type 2 diabetes mellitus is characterized by insulin resistance and defects in insulin secretion from pancreatic beta-cells, which have been studied by using euglycemic/hyperinsulinemic clamps. However, it is difficult to study insulin resistance and beta-cell failure by these techniques in humans. Therefore, the aim of this study was to evaluate the effect of three different antidiabetic therapeutic regimens on insulin resistance and beta-cell activity by using a mathematical model, Homeostasis Model Assessment for insulin resistance (HOMA(IR)) and beta-cell function (HOMA(beta-cell)).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1075-2765
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pubmed:author |
pubmed-author:Bermúdez-AriasFernandoF,
pubmed-author:Bermúdez-PirelaValmore JVJ,
pubmed-author:CanoClímacoC,
pubmed-author:CanoRaquelR,
pubmed-author:CiscekAnaA,
pubmed-author:ContrerasFreddyF,
pubmed-author:Hernández-HernándezRafaelR,
pubmed-author:IsrailiZafar HZH,
pubmed-author:LealElliuz MEM,
pubmed-author:LemusMiguel AMA,
pubmed-author:MedinaMayerlim TMT,
pubmed-author:SeyfiHamid AHA,
pubmed-author:SoukiAidaA,
pubmed-author:ValascoManuelM
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
194-202
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17414590-Blood Glucose,
pubmed-meshheading:17414590-Diabetes Mellitus, Type 2,
pubmed-meshheading:17414590-Diet,
pubmed-meshheading:17414590-Drug Therapy, Combination,
pubmed-meshheading:17414590-Female,
pubmed-meshheading:17414590-Hemoglobin A, Glycosylated,
pubmed-meshheading:17414590-Humans,
pubmed-meshheading:17414590-Hyperinsulinism,
pubmed-meshheading:17414590-Hypoglycemic Agents,
pubmed-meshheading:17414590-Insulin,
pubmed-meshheading:17414590-Insulin Resistance,
pubmed-meshheading:17414590-Insulin-Secreting Cells,
pubmed-meshheading:17414590-Male,
pubmed-meshheading:17414590-Metformin,
pubmed-meshheading:17414590-Middle Aged,
pubmed-meshheading:17414590-Models, Biological,
pubmed-meshheading:17414590-Motor Activity,
pubmed-meshheading:17414590-Sulfonylurea Compounds
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pubmed:articleTitle |
Metformin plus low-dose glimeperide significantly improves Homeostasis Model Assessment for insulin resistance (HOMA(IR)) and beta-cell function (HOMA(beta-cell)) without hyperinsulinemia in patients with type 2 diabetes mellitus.
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pubmed:affiliation |
Endocrine and Metabolic Diseases Research Center Dr. Félix Gómez, University of Zulia School of Medicine, Maracaibo, Venezuela. vbermudez@hotmail.com
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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