| pubmed-article:17404305 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C0026912 | lld:lifeskim |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C2346689 | lld:lifeskim |
| pubmed-article:17404305 | lifeskim:mentions | umls-concept:C1550025 | lld:lifeskim |
| pubmed-article:17404305 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17404305 | pubmed:dateCreated | 2007-4-3 | lld:pubmed |
| pubmed-article:17404305 | pubmed:abstractText | Distinct IFN-gamma and IL-2 profiles of Ag-specific CD4(+) T cells have recently been associated with different clinical disease states and Ag loads in viral infections. We assessed the kinetics and functional profile of Mycobacterium tuberculosis Ag-specific T cells secreting IFN-gamma and IL-2 in 23 patients with untreated active tuberculosis when bacterial and Ag loads are high and after curative treatment, when Ag load is reduced. The frequencies of M. tuberculosis Ag-specific IFN-gamma-secreting T cells declined during 28 mo of follow-up with an average percentage decline of 5.8% per year (p = 0.005), while the frequencies of Ag-specific IL-2-secreting T cells increased during treatment (p = 0.02). These contrasting dynamics for the two cytokines led to a progressive convergence of the frequencies of IFN-gamma- and IL-2-secreting cells over 28 mo. Simultaneous measurement of IFN-gamma and IL-2 secretion at the single-cell level revealed a codominance of IFN-gamma-only secreting and IFN-gamma/IL-2 dual secreting CD4(+) T cells in active disease that shifted to dominance of IFN-gamma/IL-2-secreting CD4(+) T cells and newly detectable IL-2-only secreting CD4(+) T cells during and after treatment. These distinct T cell functional signatures before and after treatment suggest a novel immunological marker of mycobacterial load and clinical status in tuberculosis that now requires validation in larger prospective studies. | lld:pubmed |
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| pubmed-article:17404305 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17404305 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17404305 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:17404305 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17404305 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17404305 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:KlenermanPaul... | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:DeeksJonathan... | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:LalvaniAjitA | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:InnesJohn AJA | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:MillingtonKer... | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:Guyot-RevolVa... | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:HackforthSara... | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:HinksTimothy... | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:DosanjhDavind... | lld:pubmed |
| pubmed-article:17404305 | pubmed:author | pubmed-author:GunatheesanRu... | lld:pubmed |
| pubmed-article:17404305 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17404305 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17404305 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:17404305 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17404305 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17404305 | pubmed:pagination | 5217-26 | lld:pubmed |
| pubmed-article:17404305 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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