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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-4-3
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pubmed:abstractText |
Distinct IFN-gamma and IL-2 profiles of Ag-specific CD4(+) T cells have recently been associated with different clinical disease states and Ag loads in viral infections. We assessed the kinetics and functional profile of Mycobacterium tuberculosis Ag-specific T cells secreting IFN-gamma and IL-2 in 23 patients with untreated active tuberculosis when bacterial and Ag loads are high and after curative treatment, when Ag load is reduced. The frequencies of M. tuberculosis Ag-specific IFN-gamma-secreting T cells declined during 28 mo of follow-up with an average percentage decline of 5.8% per year (p = 0.005), while the frequencies of Ag-specific IL-2-secreting T cells increased during treatment (p = 0.02). These contrasting dynamics for the two cytokines led to a progressive convergence of the frequencies of IFN-gamma- and IL-2-secreting cells over 28 mo. Simultaneous measurement of IFN-gamma and IL-2 secretion at the single-cell level revealed a codominance of IFN-gamma-only secreting and IFN-gamma/IL-2 dual secreting CD4(+) T cells in active disease that shifted to dominance of IFN-gamma/IL-2-secreting CD4(+) T cells and newly detectable IL-2-only secreting CD4(+) T cells during and after treatment. These distinct T cell functional signatures before and after treatment suggest a novel immunological marker of mycobacterial load and clinical status in tuberculosis that now requires validation in larger prospective studies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-10348738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-10537110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-10558973,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-12165552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-12441800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-12461571,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-14986262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-14986263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15032588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15130907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15194806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15265931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15343366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15484193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15634928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15825033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-15841456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-16158897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-16254352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-16339919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-16573826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-16622477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-16709858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-7504064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-8245795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-8600537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-9294140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-9728545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404305-9818540
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5217-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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