|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0065936,
umls-concept:C0086605,
umls-concept:C0174680,
umls-concept:C0185117,
umls-concept:C0243071,
umls-concept:C0521447,
umls-concept:C1518174,
umls-concept:C1521761,
umls-concept:C1879547,
umls-concept:C2239176,
umls-concept:C2911684
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2007-4-3
|
|
pubmed:abstractText |
Menatetrenone, a vitamin K2 analogue, plays an important role in the production of blood coagulation factors. Menatetrenone has also bee shown to have antineoplastic effects against several cancer cell lines including hepatocellular carcinoma (HCC) cells. However, the mechanisms by which vitamin K2 inhibits HCC cell growth have not bee fully clarified, and we therefore investigated the molecular basis of vitamin K2-induced growth inhibition of HCC cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2236-45
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:17404108-Antineoplastic Agents,
pubmed-meshheading:17404108-Blotting, Western,
pubmed-meshheading:17404108-Carcinoma, Hepatocellular,
pubmed-meshheading:17404108-Cell Line, Tumor,
pubmed-meshheading:17404108-Cell Proliferation,
pubmed-meshheading:17404108-Cell Separation,
pubmed-meshheading:17404108-Cyclin D1,
pubmed-meshheading:17404108-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:17404108-Enzyme Activation,
pubmed-meshheading:17404108-Flow Cytometry,
pubmed-meshheading:17404108-Humans,
pubmed-meshheading:17404108-I-kappa B Kinase,
pubmed-meshheading:17404108-Liver Neoplasms,
pubmed-meshheading:17404108-NF-kappa B,
pubmed-meshheading:17404108-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17404108-Transcription, Genetic,
pubmed-meshheading:17404108-Transfection,
pubmed-meshheading:17404108-Vitamin K 2
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation.
|
|
pubmed:affiliation |
Division of Hepatology and Metabolism, Department of Internal Medicine, and Health Administration Center, Saga Medical School, Saga University, Nabeshima, Saga, Japan. ozaki@cc.saga-u.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
