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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-7-24
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pubmed:abstractText |
Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-9564
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1065-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17401528-Adult,
pubmed-meshheading:17401528-Aged,
pubmed-meshheading:17401528-Antidepressive Agents,
pubmed-meshheading:17401528-Brain,
pubmed-meshheading:17401528-Brain Chemistry,
pubmed-meshheading:17401528-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:17401528-DNA Mutational Analysis,
pubmed-meshheading:17401528-Depressive Disorder,
pubmed-meshheading:17401528-Drug Resistance,
pubmed-meshheading:17401528-Electroconvulsive Therapy,
pubmed-meshheading:17401528-Female,
pubmed-meshheading:17401528-Gene Frequency,
pubmed-meshheading:17401528-Genetic Markers,
pubmed-meshheading:17401528-Genetic Predisposition to Disease,
pubmed-meshheading:17401528-Genetic Testing,
pubmed-meshheading:17401528-Genotype,
pubmed-meshheading:17401528-Humans,
pubmed-meshheading:17401528-Male,
pubmed-meshheading:17401528-Middle Aged,
pubmed-meshheading:17401528-Polymorphism, Genetic,
pubmed-meshheading:17401528-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:17401528-Risk Factors,
pubmed-meshheading:17401528-Serotonin,
pubmed-meshheading:17401528-Treatment Failure
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pubmed:year |
2007
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pubmed:articleTitle |
Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression.
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pubmed:affiliation |
Medical School, University of Tampere, Tampere, Finland. samia@koti.soon.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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