| pubmed-article:17401465 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17401465 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:17401465 | lifeskim:mentions | umls-concept:C0026948 | lld:lifeskim |
| pubmed-article:17401465 | lifeskim:mentions | umls-concept:C0032923 | lld:lifeskim |
| pubmed-article:17401465 | lifeskim:mentions | umls-concept:C0033666 | lld:lifeskim |
| pubmed-article:17401465 | lifeskim:mentions | umls-concept:C0162491 | lld:lifeskim |
| pubmed-article:17401465 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17401465 | pubmed:dateCreated | 2007-4-2 | lld:pubmed |
| pubmed-article:17401465 | pubmed:abstractText | Cutaneous T-cell lymphomas (CTCLs) are characterized by the recruitment of malignant T-cell clones, predominantly of the CD4(+) T-helper subpopulation, into the skin. Mycosis fungoides (MF) is the most common type of CTCL and accounts for almost 50% of all primary cutaneous lymphomas. The ProteinChip technology surface-enhanced laser desorption/ionization time of flight/mass spectrometry (SELDI-TOF-MS) was used to detect biomarkers in sera from MF patients (n = 25) and healthy controls (n = 26). Therefore, diluted sera were applied to IMAC30 ProteinChip arrays, and the resulting protein profiles were bioinformatically analyzed. A protein set that distinguishes MF patients from healthy controls with a sensitivity of 82.6% and a specificity of 100% was identified. Four significant peaks were identified by two-dimensional gel electrophoresis, immunodepletion, and SELDI-TOF-MS as transthyretin (TTR) and three TTR modifications. A subsequent enzyme-linked immunosorbent assay confirmed these findings. The ability to detect and identify proteins and protein modifications using SELDI-TOF-MS might reveal a better insight on this kind of disease and may lead to a better understanding and earlier detection of MF patients. | lld:pubmed |
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| pubmed-article:17401465 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17401465 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17401465 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17401465 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17401465 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17401465 | pubmed:issn | 1476-5586 | lld:pubmed |
| pubmed-article:17401465 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:17401465 | pubmed:author | pubmed-author:WollinaUweU | lld:pubmed |
| pubmed-article:17401465 | pubmed:author | pubmed-author:MelleChristia... | lld:pubmed |
| pubmed-article:17401465 | pubmed:author | pubmed-author:KaatzMartinM | lld:pubmed |
| pubmed-article:17401465 | pubmed:author | pubmed-author:DrieschDomini... | lld:pubmed |
| pubmed-article:17401465 | pubmed:author | pubmed-author:ZiemerMirjana... | lld:pubmed |
| pubmed-article:17401465 | pubmed:author | pubmed-author:HiplerChristi... | lld:pubmed |
| pubmed-article:17401465 | pubmed:author | pubmed-author:EscherNikoN | lld:pubmed |
| pubmed-article:17401465 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17401465 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:17401465 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17401465 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17401465 | pubmed:pagination | 254-9 | lld:pubmed |
| pubmed-article:17401465 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17401465 | pubmed:meshHeading | pubmed-meshheading:17401465... | lld:pubmed |
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| pubmed-article:17401465 | pubmed:meshHeading | pubmed-meshheading:17401465... | lld:pubmed |
| pubmed-article:17401465 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17401465 | pubmed:articleTitle | Posttranslational modifications of transthyretin are serum markers in patients with mycosis fungoides. | lld:pubmed |
| pubmed-article:17401465 | pubmed:affiliation | Core Unit Chip Application, Institute of Human Genetics and Anthropology, Medical Faculty, Friedrich-Schiller-University, Jena 07740, Germany. | lld:pubmed |
| pubmed-article:17401465 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17401465 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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