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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-4-2
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pubmed:abstractText |
Cutaneous T-cell lymphomas (CTCLs) are characterized by the recruitment of malignant T-cell clones, predominantly of the CD4(+) T-helper subpopulation, into the skin. Mycosis fungoides (MF) is the most common type of CTCL and accounts for almost 50% of all primary cutaneous lymphomas. The ProteinChip technology surface-enhanced laser desorption/ionization time of flight/mass spectrometry (SELDI-TOF-MS) was used to detect biomarkers in sera from MF patients (n = 25) and healthy controls (n = 26). Therefore, diluted sera were applied to IMAC30 ProteinChip arrays, and the resulting protein profiles were bioinformatically analyzed. A protein set that distinguishes MF patients from healthy controls with a sensitivity of 82.6% and a specificity of 100% was identified. Four significant peaks were identified by two-dimensional gel electrophoresis, immunodepletion, and SELDI-TOF-MS as transthyretin (TTR) and three TTR modifications. A subsequent enzyme-linked immunosorbent assay confirmed these findings. The ability to detect and identify proteins and protein modifications using SELDI-TOF-MS might reveal a better insight on this kind of disease and may lead to a better understanding and earlier detection of MF patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-10722267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-11084869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-12689942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-12782714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-12824440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-15313933,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-15692063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-15704152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-15750015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-16237736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-16240287,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-16489655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-16522680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-16528355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-16552785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-16632030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-16650175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-6882017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-6883385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-7661601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-8522490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17401465-8713059
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1476-5586
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
254-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17401465-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:17401465-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17401465-Humans,
pubmed-meshheading:17401465-Mycosis Fungoides,
pubmed-meshheading:17401465-Prealbumin,
pubmed-meshheading:17401465-Protein Array Analysis,
pubmed-meshheading:17401465-Protein Processing, Post-Translational,
pubmed-meshheading:17401465-Skin Neoplasms,
pubmed-meshheading:17401465-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:17401465-Tumor Markers, Biological
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pubmed:year |
2007
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pubmed:articleTitle |
Posttranslational modifications of transthyretin are serum markers in patients with mycosis fungoides.
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pubmed:affiliation |
Core Unit Chip Application, Institute of Human Genetics and Anthropology, Medical Faculty, Friedrich-Schiller-University, Jena 07740, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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