Linked Life Data

17401374

Source:http://linkedlifedata.com/resource/pubmed/id/17401374

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17401374rdf:typepubmed:Citationlld:pubmed
pubmed-article:17401374lifeskim:mentionsumls-concept:C0035647lld:lifeskim
pubmed-article:17401374lifeskim:mentionsumls-concept:C0018787lld:lifeskim
pubmed-article:17401374lifeskim:mentionsumls-concept:C1101610lld:lifeskim
pubmed-article:17401374lifeskim:mentionsumls-concept:C1415068lld:lifeskim
pubmed-article:17401374lifeskim:mentionsumls-concept:C1416584lld:lifeskim
pubmed-article:17401374lifeskim:mentionsumls-concept:C0599894lld:lifeskim
pubmed-article:17401374lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:17401374pubmed:issue4lld:pubmed
pubmed-article:17401374pubmed:dateCreated2007-4-6lld:pubmed
pubmed-article:17401374pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:abstractTextMicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mRNAs. Our current understanding of the functions of miRNAs relies mainly on their tissue-specific or developmental stage-dependent expression and their evolutionary conservation, and therefore is primarily limited to their involvement in developmental regulation and oncogenesis. Of more than 300 miRNAs that have been identified, miR-1 and miR-133 are considered to be muscle specific. Here we show that miR-1 is overexpressed in individuals with coronary artery disease, and that when overexpressed in normal or infarcted rat hearts, it exacerbates arrhythmogenesis. Elimination of miR-1 by an antisense inhibitor in infarcted rat hearts relieved arrhythmogenesis. miR-1 overexpression slowed conduction and depolarized the cytoplasmic membrane by post-transcriptionally repressing KCNJ2 (which encodes the K(+) channel subunit Kir2.1) and GJA1 (which encodes connexin 43), and this likely accounts at least in part for its arrhythmogenic potential. Thus, miR-1 may have important pathophysiological functions in the heart, and is a potential antiarrhythmic target.lld:pubmed
pubmed-article:17401374pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:languageenglld:pubmed
pubmed-article:17401374pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:citationSubsetIMlld:pubmed
pubmed-article:17401374pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17401374pubmed:statusMEDLINElld:pubmed
pubmed-article:17401374pubmed:monthAprlld:pubmed
pubmed-article:17401374pubmed:issn1078-8956lld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:ZhangYingYlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:WangZhiguoZlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:LiBaoxinBlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:LuYanjieYlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:WangHuizhenHlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:YangBaofengBlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:LinHuixianHlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:XuChaoqianClld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:ChenGuohaoGlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:XiaoJieningJlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:LuoXiaobinXlld:pubmed
pubmed-article:17401374pubmed:authorpubmed-author:BaiYunlongYlld:pubmed
pubmed-article:17401374pubmed:issnTypePrintlld:pubmed
pubmed-article:17401374pubmed:volume13lld:pubmed
pubmed-article:17401374pubmed:ownerNLMlld:pubmed
pubmed-article:17401374pubmed:authorsCompleteYlld:pubmed
pubmed-article:17401374pubmed:pagination486-91lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:meshHeadingpubmed-meshheading:17401374...lld:pubmed
pubmed-article:17401374pubmed:year2007lld:pubmed
pubmed-article:17401374pubmed:articleTitleThe muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2.lld:pubmed
pubmed-article:17401374pubmed:affiliationDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang 150086, China. yangbf@ems.hrbmu.edu.cnlld:pubmed
pubmed-article:17401374pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17401374pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:2697entrezgene:pubmedpubmed-article:17401374lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17401374lld:pubmed
More...