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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-4-6
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pubmed:databankReference |
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pubmed:abstractText |
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mRNAs. Our current understanding of the functions of miRNAs relies mainly on their tissue-specific or developmental stage-dependent expression and their evolutionary conservation, and therefore is primarily limited to their involvement in developmental regulation and oncogenesis. Of more than 300 miRNAs that have been identified, miR-1 and miR-133 are considered to be muscle specific. Here we show that miR-1 is overexpressed in individuals with coronary artery disease, and that when overexpressed in normal or infarcted rat hearts, it exacerbates arrhythmogenesis. Elimination of miR-1 by an antisense inhibitor in infarcted rat hearts relieved arrhythmogenesis. miR-1 overexpression slowed conduction and depolarized the cytoplasmic membrane by post-transcriptionally repressing KCNJ2 (which encodes the K(+) channel subunit Kir2.1) and GJA1 (which encodes connexin 43), and this likely accounts at least in part for its arrhythmogenic potential. Thus, miR-1 may have important pathophysiological functions in the heart, and is a potential antiarrhythmic target.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Connexin 43,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/GJA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KCNJ2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Myogenic Regulatory Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:BaiYunlongY,
pubmed-author:ChenGuohaoG,
pubmed-author:LiBaoxinB,
pubmed-author:LinHuixianH,
pubmed-author:LuYanjieY,
pubmed-author:LuoXiaobinX,
pubmed-author:WangHuizhenH,
pubmed-author:WangZhiguoZ,
pubmed-author:XiaoJieningJ,
pubmed-author:XuChaoqianC,
pubmed-author:YangBaofengB,
pubmed-author:ZhangYingY
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
486-91
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pubmed:meshHeading |
pubmed-meshheading:17401374-Action Potentials,
pubmed-meshheading:17401374-Animals,
pubmed-meshheading:17401374-Arrhythmias, Cardiac,
pubmed-meshheading:17401374-Base Sequence,
pubmed-meshheading:17401374-Calcium-Calmodulin-Dependent Protein Kinase Type 2,
pubmed-meshheading:17401374-Connexin 43,
pubmed-meshheading:17401374-Coronary Artery Disease,
pubmed-meshheading:17401374-DNA Primers,
pubmed-meshheading:17401374-Electrocardiography,
pubmed-meshheading:17401374-Gene Expression Regulation,
pubmed-meshheading:17401374-Humans,
pubmed-meshheading:17401374-MicroRNAs,
pubmed-meshheading:17401374-Molecular Sequence Data,
pubmed-meshheading:17401374-Mutagenesis,
pubmed-meshheading:17401374-Myogenic Regulatory Factors,
pubmed-meshheading:17401374-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:17401374-Rats,
pubmed-meshheading:17401374-Sequence Analysis, DNA,
pubmed-meshheading:17401374-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2.
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pubmed:affiliation |
Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang 150086, China. yangbf@ems.hrbmu.edu.cn
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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