Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1992-3-13
|
pubmed:abstractText |
The effect of rapamycin (RAPA) on both host-versus-graft (HVG) and graft-versus-host (GVH) immune responses was examined in small bowel transplant models using strongly histoincompatible donor-recipient combinations. Normal Wistar Furth (WFu; RT-1u) recipients rejected Buffalo (BUF; RT-1b) small bowel allografts within a mean survival time (MST) of 10.5 +/- 0.5 days. Administration of RAPA (0.8 mg/kg) by continuous intravenous infusion for 14 days via an osmotic pump prolonged graft survival to 25.0 +/- 4.6 days (P = 0.01). In a second strain combination, the 12.5 +/- 2.2 day survival of Brown Norway (BN; RT-1n) small bowel allografts in Lewis (RT-1l) recipients was prolonged to 21.6 +/- 2.0 and 28.5 +/- 2.8 days by 14 days of i.v. RAPA at doses of 0.8 and 1.6 mg/kg, respectively. In this model RAPA is five times more effective than cyclosporine, which at 4.0 mg/kg prolongs BN small bowel allografts in Lewis recipients to 21.6 +/- 6.3. To isolate HVG and GVH immune responses, (BN x Lewis)F1 hybrid rats served as the graft donor or host, respectively. In the HVG model, (BN x Lewis)F1 small bowel allografts, which were rejected by normal Lewis recipients at 12.2 +/- 3.6 days, were prolonged to 40.8 +/- 5.8 days (P = 0.001) by RAPA (0.8 mg/kg x 14 days). In the GVH model, the ability of Lewis small bowel allografts to produce severe GVH disease in untreated (BN x Lewis)F1 recipients at 12.3 +/- 2.8 days was delayed to 21.3 +/- 5.2 days by 0.8 mg/kg RAPA (P = 0.025). Thus, RAPA protects small bowel allografts more effectively against HVG than GVH immune responses.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Maltose,
http://linkedlifedata.com/resource/pubmed/chemical/Polyenes,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0041-1337
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
53
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
258-64
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:1738917-Animals,
pubmed-meshheading:1738917-Body Weight,
pubmed-meshheading:1738917-Cyclosporine,
pubmed-meshheading:1738917-Dose-Response Relationship, Drug,
pubmed-meshheading:1738917-Graft Survival,
pubmed-meshheading:1738917-Graft vs Host Reaction,
pubmed-meshheading:1738917-Host vs Graft Reaction,
pubmed-meshheading:1738917-Immunosuppressive Agents,
pubmed-meshheading:1738917-Intestinal Absorption,
pubmed-meshheading:1738917-Intestine, Small,
pubmed-meshheading:1738917-Male,
pubmed-meshheading:1738917-Maltose,
pubmed-meshheading:1738917-Polyenes,
pubmed-meshheading:1738917-Rats,
pubmed-meshheading:1738917-Rats, Inbred BN,
pubmed-meshheading:1738917-Rats, Inbred BUF,
pubmed-meshheading:1738917-Rats, Inbred Lew,
pubmed-meshheading:1738917-Rats, Inbred WF,
pubmed-meshheading:1738917-Sirolimus,
pubmed-meshheading:1738917-Transplantation, Homologous
|
pubmed:year |
1992
|
pubmed:articleTitle |
Inhibition of host-versus-graft and graft-versus-host responses after small bowel transplantation in rats by rapamycin.
|
pubmed:affiliation |
Department of Surgery, University of Texas Medical School, Houston 77030.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|