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rdf:type |
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|
lifeskim:mentions |
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|
pubmed:issue |
7
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pubmed:dateCreated |
2007-5-22
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pubmed:abstractText |
Oral delivery of salmon calcitonin (sCT) to rats via a recombinant Saccharomyces cerevisiae was assessed. A synthetic sCT gene was cloned and expressed in S. cerevisiae yAGA2-sCT. Recombinant salmon calcitonin (rsCT) expression was detected by flow cytometry. The resorption activity of osteoclasts was inhibited by 3 x 10(-6 )M rsCT. Oral administration of 5 g lyophilized yAGA2-sCT/kg to hypercalcemic rats decreased serum calcium from 2.8 +/- 0.02-2.7 +/- 0.02 mM.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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|
pubmed:issn |
0141-5492
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
29
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1013-8
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pubmed:meshHeading |
pubmed-meshheading:17387434-Administration, Oral,
pubmed-meshheading:17387434-Animals,
pubmed-meshheading:17387434-Bone Resorption,
pubmed-meshheading:17387434-Calcitonin,
pubmed-meshheading:17387434-Calcium,
pubmed-meshheading:17387434-Cattle,
pubmed-meshheading:17387434-Flow Cytometry,
pubmed-meshheading:17387434-Gene Expression,
pubmed-meshheading:17387434-Genetic Vectors,
pubmed-meshheading:17387434-Hypercalcemia,
pubmed-meshheading:17387434-Male,
pubmed-meshheading:17387434-Rats,
pubmed-meshheading:17387434-Rats, Wistar,
pubmed-meshheading:17387434-Recombinant Proteins,
pubmed-meshheading:17387434-Saccharomyces cerevisiae
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pubmed:year |
2007
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|
pubmed:articleTitle |
Anti-hypercalcemic effect of orally administered recombinant Saccharomyces cerevisiae expressing salmon calcitonin on hypercalcemic rats.
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pubmed:affiliation |
College of Marine Life Sciences, Ocean University of China, Qingdao, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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