|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2007-3-27
|
|
pubmed:abstractText |
To understand the response of murine uterine natural killer (uNK) cells to Toll-like receptor (TLR) 3 agonist at the early gestation stage, CBA x DBA/2 mice were intraperitoneally (i.p.) injected with polyinosinic-polycytidylic acid (poly I:C), the specific TLR3 agonist, at a dose of 10 microg/g BW or PBS at gestation day (gd) 6.5. The CD69 expression of uNK (DX5(+)CD3(-)) cells was highly up-regulated and reached 92.3+/-0.9%, the percentage of intracellular TNF-alpha(+) or IFN-gamma(+) uNK (DX5(+)CD3(-)) cells in the implantation sites of CBAxDBA/2 matings was also significantly increased 24 h after poly I:C injection. Surprisingly, poly I:C treatment significantly decreased the total number of uNK cells (either DX5(+)CD3(-) or DBA(+)) at fetal-maternal surface, but had no influence on local NKT cells, T cells and DCs. This investigation will help to explain the central role for hyperactivated uNK cells in the progress of mice pregnancy.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11c,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Inducers,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Poly I-C,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 3,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1567-5769
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
588-96
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17386406-Animals,
pubmed-meshheading:17386406-Antigens, CD,
pubmed-meshheading:17386406-Antigens, CD11c,
pubmed-meshheading:17386406-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:17386406-Cell Separation,
pubmed-meshheading:17386406-Female,
pubmed-meshheading:17386406-Fluorescent Antibody Technique,
pubmed-meshheading:17386406-Interferon Inducers,
pubmed-meshheading:17386406-Interferon-gamma,
pubmed-meshheading:17386406-Killer Cells, Natural,
pubmed-meshheading:17386406-Lectins, C-Type,
pubmed-meshheading:17386406-Mice,
pubmed-meshheading:17386406-Mice, Inbred CBA,
pubmed-meshheading:17386406-Mice, Inbred DBA,
pubmed-meshheading:17386406-Poly I-C,
pubmed-meshheading:17386406-Pregnancy,
pubmed-meshheading:17386406-Toll-Like Receptor 3,
pubmed-meshheading:17386406-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17386406-Uterus
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Toll-like receptor 3 agonist enhances IFN-gamma and TNF-alpha production by murine uterine NK cells.
|
|
pubmed:affiliation |
Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale, China; School of Life Sciences, University of Science and Technology of China, 443 Huangshan Road, Hefei, Anhui 230027, China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
