Linked Life Data

17384421

Source:http://linkedlifedata.com/resource/pubmed/id/17384421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-8-16
pubmed:abstractText
Transcription factors (TF) play a key role in certain mechanisms by which specific genes are expressed in a temporal and tissue-specific manner. Understanding those mechanisms is still a challenging question in biology. Their modular organization allows the possibility of classifying them based on the structure of the domains that bind DNA or interact with other proteins. Those domains not only define the different TF families but also provide insights into the biological functions played by them. Among these, the POK (Poxviruses and Zinc-finger (POZ) and Krüppel) family of transcription repressors is characterized by the presence in their structures of an amino-terminal POZ/Broad Complex, Tramtrack, and Bric à brac (BTB) domain and several Krüppel-type zinc fingers at the carboxy-terminal moiety. The POZ/BTB domain mediates homo- and heterodimerization as well as protein-protein interactions, allowing the recruitment of corepressor complexes. On the other hand, the specific zinc fingers mediate specific DNA sequences recognition and binding. In the last few years, several reports have highlighted the importance that this family of transcriptional repressors plays in different processes such as cancer, development and stem cell biology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1473-9550
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Functional analysis of the role of POK transcriptional repressors.
pubmed:affiliation
Molecular Oncology Lab, Departamento de Fisioloxia, Facultade de Medicina, Universidade de Santiago de Compostela, Rua San Francisco s/n, 15782 Santiago de Compostela, Spain. jcostoya@usc.es
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't