rdf:type |
|
lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0021853,
umls-concept:C0031676,
umls-concept:C0033262,
umls-concept:C0205314,
umls-concept:C0220825,
umls-concept:C0243125,
umls-concept:C0301869,
umls-concept:C0441712,
umls-concept:C0442027,
umls-concept:C0549178,
umls-concept:C0679622,
umls-concept:C0699900,
umls-concept:C0868939
|
pubmed:issue |
1
|
pubmed:dateCreated |
2007-4-19
|
pubmed:abstractText |
To investigate a novel mechanism for oral controlled release of drugs involving a continuous degradation of a phospholipid prodrug along the intestine. An indomethacin-lecithin conjugate with the drug attached to the sn-2 position of the phospholipid through a 5-carbon linker (DP-155) was used as a model molecule.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1873-4995
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
14
|
pubmed:volume |
119
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
86-93
|
pubmed:meshHeading |
pubmed-meshheading:17382425-Administration, Oral,
pubmed-meshheading:17382425-Animals,
pubmed-meshheading:17382425-Biological Availability,
pubmed-meshheading:17382425-Delayed-Action Preparations,
pubmed-meshheading:17382425-Drug Evaluation, Preclinical,
pubmed-meshheading:17382425-Indomethacin,
pubmed-meshheading:17382425-Intestines,
pubmed-meshheading:17382425-Male,
pubmed-meshheading:17382425-Phosphatidylcholines,
pubmed-meshheading:17382425-Phospholipids,
pubmed-meshheading:17382425-Prodrugs,
pubmed-meshheading:17382425-Rats,
pubmed-meshheading:17382425-Rats, Wistar
|
pubmed:year |
2007
|
pubmed:articleTitle |
A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: in-vivo and in-vitro evaluation of an indomethacin-lecithin conjugate.
|
pubmed:affiliation |
Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|