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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-5-24
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pubmed:abstractText |
Tissue factor (TF) initiates coagulation and indirectly triggers thrombin-dependent protease activated receptor (PAR) signaling. The TF-VIIa complex also directly cleaves PAR2 and promotes angiogenesis in vitro in TF cytoplasmic domain-deleted (TF(deltaCT)) mice. Here we address the effect of PAR1 and PAR2 deficiency on angiogenesis in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Coagulation Factor Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Factor VIIa,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, PAR-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, PAR-2,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboplastin,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1456-62
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17363687-Animals,
pubmed-meshheading:17363687-Anoxia,
pubmed-meshheading:17363687-Blood Coagulation Factor Inhibitors,
pubmed-meshheading:17363687-Cell Line, Tumor,
pubmed-meshheading:17363687-Disease Models, Animal,
pubmed-meshheading:17363687-Factor VIIa,
pubmed-meshheading:17363687-Hyperoxia,
pubmed-meshheading:17363687-Mice,
pubmed-meshheading:17363687-Mice, Inbred C57BL,
pubmed-meshheading:17363687-Mice, Knockout,
pubmed-meshheading:17363687-Mice, Transgenic,
pubmed-meshheading:17363687-Neoplasms, Experimental,
pubmed-meshheading:17363687-Neovascularization, Pathologic,
pubmed-meshheading:17363687-Oxygen,
pubmed-meshheading:17363687-Piperazines,
pubmed-meshheading:17363687-Protein Kinase Inhibitors,
pubmed-meshheading:17363687-Pyrimidines,
pubmed-meshheading:17363687-Receptor, PAR-1,
pubmed-meshheading:17363687-Receptor, PAR-2,
pubmed-meshheading:17363687-Retinal Neovascularization,
pubmed-meshheading:17363687-Retinal Vessels,
pubmed-meshheading:17363687-Signal Transduction,
pubmed-meshheading:17363687-Thromboplastin,
pubmed-meshheading:17363687-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis.
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pubmed:affiliation |
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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