| pubmed-article:1735191 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C0005767 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C0035245 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C0014457 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C0149783 | lld:lifeskim |
| pubmed-article:1735191 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:1735191 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1735191 | pubmed:dateCreated | 1992-3-12 | lld:pubmed |
| pubmed-article:1735191 | pubmed:abstractText | Evidence now suggests that eosinophils and T lymphocytes infiltrating bronchial tissues may play a key role in the pathophysiology of asthma. Circulating eosinophils, lung function, and plasma soluble IL-2 receptor (sIL-2R) were measured in 42 asthmatic patients referred for symptomatic asthma. The patients were divided into two groups based on the presence or absence of atopy. The group of non-atopic asthmatics was further divided according to the patients' requirement for long term oral corticosteroids. The mean sIL-2R +/- s.d. was 36.3 +/- 9.9 pM in the control group, 28.9 +/- 9.2 pM in the atopic asthmatics, 43.3 +/- 18.07 pM in the non-atopic asthmatics without oral steroid therapy, but was increased in the steroid-treated group (62.2 +/- 19.3 pM, P less than 0.01). A significant correlation was found between FEV1 and circulating eosinophils in atopic asthmatics and in non-atopic asthmatics without oral corticosteroid therapy, but not in the steroid-treated group. Furthermore, significant correlations were found between sIL-2R and FEV1, and between sIL-2R and blood eosinophils, in the group of non-atopic asthmatics not on oral steroid therapy. No such correlations were evidenced in the other groups of asthmatics. Similar results were obtained during the clinical course of three non-atopic patients followed for more than 1 year. These data suggest that T cell activation appears more prominent in non-atopic asthma than in atopic asthma. Moreover, it appears that T cell activation can occur in severe forms of asthma despite steroid treatment. Finally, the results suggest a possible link between T cell activation, eosinophils, and lung function, which may reflect a particular pathogenetic mechanism involved in non-atopic asthma. | lld:pubmed |
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| pubmed-article:1735191 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1735191 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1735191 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1735191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1735191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1735191 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1735191 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1735191 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:TonnelA BAB | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:CapronAA | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:JosephMM | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:WallaertBB | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:SergantMM | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:ZandeckiMM | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:LassallePP | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:DelnesteYY | lld:pubmed |
| pubmed-article:1735191 | pubmed:author | pubmed-author:GossetPP | lld:pubmed |
| pubmed-article:1735191 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1735191 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:1735191 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1735191 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1735191 | pubmed:pagination | 266-71 | lld:pubmed |
| pubmed-article:1735191 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:1735191 | pubmed:meshHeading | pubmed-meshheading:1735191-... | lld:pubmed |
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| pubmed-article:1735191 | pubmed:meshHeading | pubmed-meshheading:1735191-... | lld:pubmed |
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| pubmed-article:1735191 | pubmed:meshHeading | pubmed-meshheading:1735191-... | lld:pubmed |
| pubmed-article:1735191 | pubmed:meshHeading | pubmed-meshheading:1735191-... | lld:pubmed |
| pubmed-article:1735191 | pubmed:meshHeading | pubmed-meshheading:1735191-... | lld:pubmed |
| pubmed-article:1735191 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1735191 | pubmed:articleTitle | Levels of soluble IL-2 receptor in plasma from asthmatics. Correlations with blood eosinophilia, lung function, and corticosteroid therapy. | lld:pubmed |
| pubmed-article:1735191 | pubmed:affiliation | C.J.F. INSERM 90-06, Institut Pasteur, Lille, France. | lld:pubmed |
| pubmed-article:1735191 | pubmed:publicationType | Journal Article | lld:pubmed |
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