Linked Life Data

1735191

Source:http://linkedlifedata.com/resource/pubmed/id/1735191

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-3-12
pubmed:abstractText
Evidence now suggests that eosinophils and T lymphocytes infiltrating bronchial tissues may play a key role in the pathophysiology of asthma. Circulating eosinophils, lung function, and plasma soluble IL-2 receptor (sIL-2R) were measured in 42 asthmatic patients referred for symptomatic asthma. The patients were divided into two groups based on the presence or absence of atopy. The group of non-atopic asthmatics was further divided according to the patients' requirement for long term oral corticosteroids. The mean sIL-2R +/- s.d. was 36.3 +/- 9.9 pM in the control group, 28.9 +/- 9.2 pM in the atopic asthmatics, 43.3 +/- 18.07 pM in the non-atopic asthmatics without oral steroid therapy, but was increased in the steroid-treated group (62.2 +/- 19.3 pM, P less than 0.01). A significant correlation was found between FEV1 and circulating eosinophils in atopic asthmatics and in non-atopic asthmatics without oral corticosteroid therapy, but not in the steroid-treated group. Furthermore, significant correlations were found between sIL-2R and FEV1, and between sIL-2R and blood eosinophils, in the group of non-atopic asthmatics not on oral steroid therapy. No such correlations were evidenced in the other groups of asthmatics. Similar results were obtained during the clinical course of three non-atopic patients followed for more than 1 year. These data suggest that T cell activation appears more prominent in non-atopic asthma than in atopic asthma. Moreover, it appears that T cell activation can occur in severe forms of asthma despite steroid treatment. Finally, the results suggest a possible link between T cell activation, eosinophils, and lung function, which may reflect a particular pathogenetic mechanism involved in non-atopic asthma.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-1124105, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-1847158, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-1970229, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-2205142, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-2215562, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-2221594, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-2252260, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-2891886, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-2923380, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-3115640, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-3660304, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-4053332, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-5073322, http://linkedlifedata.com/resource/pubmed/commentcorrection/1735191-6177986
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
266-71
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Levels of soluble IL-2 receptor in plasma from asthmatics. Correlations with blood eosinophilia, lung function, and corticosteroid therapy.
pubmed:affiliation
C.J.F. INSERM 90-06, Institut Pasteur, Lille, France.
pubmed:publicationType
Journal Article