rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2007-4-17
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pubmed:abstractText |
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been associated with both overall schizophrenia risk and severity of negative symptoms. This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this relationship.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0920-9964
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-8
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:17344026-Adult,
pubmed-meshheading:17344026-Affect,
pubmed-meshheading:17344026-Cognition Disorders,
pubmed-meshheading:17344026-Female,
pubmed-meshheading:17344026-Genotype,
pubmed-meshheading:17344026-Humans,
pubmed-meshheading:17344026-Male,
pubmed-meshheading:17344026-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:17344026-Middle Aged,
pubmed-meshheading:17344026-Neuropsychological Tests,
pubmed-meshheading:17344026-Polymorphism, Genetic,
pubmed-meshheading:17344026-Schizophrenia,
pubmed-meshheading:17344026-Severity of Illness Index,
pubmed-meshheading:17344026-Verbal Behavior,
pubmed-meshheading:17344026-Verbal Learning
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia.
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pubmed:affiliation |
Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA. jroffman@partners.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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