rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1992-3-3
|
pubmed:abstractText |
Our current protocol for treatment of childhood acute lymphoblastic leukemia (ALL) was designed to assess the efficacy of methotrexate (MTX) plus L-asparaginase and of etopisode (VP-16) plus cytarabine (ARA-C) during intensive consolidation and continuation therapies and to determine the feasibility of intensifying MTX therapy by the use of divided oral doses of MTX. The protocol was associated with unexpected acute neurotoxicity. There are few reports of such toxic effects during therapy for ALL.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0027-8874
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
19
|
pubmed:volume |
84
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
252-6
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1734087-Adolescent,
pubmed-meshheading:1734087-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1734087-Asparaginase,
pubmed-meshheading:1734087-Child,
pubmed-meshheading:1734087-Child, Preschool,
pubmed-meshheading:1734087-Cytarabine,
pubmed-meshheading:1734087-Etoposide,
pubmed-meshheading:1734087-Female,
pubmed-meshheading:1734087-Humans,
pubmed-meshheading:1734087-Infant,
pubmed-meshheading:1734087-Leucovorin,
pubmed-meshheading:1734087-Male,
pubmed-meshheading:1734087-Methotrexate,
pubmed-meshheading:1734087-Nervous System Diseases,
pubmed-meshheading:1734087-Precursor Cell Lymphoblastic Leukemia-Lymphoma
|
pubmed:year |
1992
|
pubmed:articleTitle |
Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia.
|
pubmed:affiliation |
Department of Pediatrics, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas 75235-9063.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|