Linked Life Data

17336600

Source:http://linkedlifedata.com/resource/pubmed/id/17336600

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-4-27
pubmed:abstractText
Slices of rat carotid bodies, or cultured glomus cells, were used to study intercellular coupling. This phenomenon occurs because gap junctions allow passage of currents and dyes from one cell to another. There is a two-way resistive coupling between glomus cells (GC/GC coupling), which is accompanied by activity of intercellular channels. Coupling between glomus cells and nerve endings is more complex. Coupling is mostly resistive from cell to nerve (GC/NE) but it is mostly capacitive in the opposite direction (NE/GC). Thus, slow electric events originating in the glomus cells can be transferred to the nerve endings. But, only electric transients can pass from nerve to cell. There is also coupling between nerve endings (NE/NE), which is mostly capacitive in either direction. Chemoreceptor stimulants (acute and chronic hypoxia, hypercapnia, acidity, cholinergic agents and dopamine) uncouple most glomus cells, accompanied by cell depolarization and decreased amplitude of junction channels. Chronic hypobaric hypoxia increases GC/NE, NE/GC and NE/NE coupling. GC/GC uncoupling seems related to transmitter secretion. Transmission across chemical synapses is aided by increased coupling from glomus cell to nerve ending.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1569-9048
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
116-22
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Electric synapses in the carotid body-nerve complex.
pubmed:affiliation
Department of Physiology, School of Medicine, University of Utah, Salt Lake City, UT 84108, USA. cee3@utah.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural