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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2007-5-28
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pubmed:abstractText |
The purpose of this study was to test the hypothesis that an intact cerebellar fastigial nucleus (CFN) is an important determinant of CO(2)-H(+) sensitivity during wakefulness. Bilateral, stainless steel microtubules were implanted into the CFN (N=9) for injection (0.5-10 microl) of the neurotoxin ibotenic acid. Two or more weeks after implantation of the microtubules, eupneic breathing and CO(2)-H(+) sensitivity did not differ significantly (P>0.10) from pre-implantation conditions. Injection of ibotenic acid (50 mM) did not significantly alter eupneic Pa(CO2) (P>0.10). The coefficient of variation of eupneic Pa(CO2) was 4.0+/-0.6 and 3.7+/-0.4% over the 2 weeks before and after the lesion, respectively. CO(2)-H(+) sensitivity expressed as inspired ventilation/Pa(CO2) decreased from 2.15+/-0.17 pre-lesion to 1.58+/-0.26 l/(min mmHg) 3-6 days post-lesion (P<0.02, -27%). There was no significant (P>0.10) recovery of sensitivity between 7 and 10 days post-lesion. The lesion also increased (P<0.05) the day-to-day variability of this index by nearly 100%. When CO(2) sensitivity was expressed as elevated inspired CO(2)/room air V (I), values at 7%, but not 3 and 5% inspired CO(2), were reduced and more variable (P<0.05) after the ibotenic acid injections. We conclude that during wakefulness, the CFN contributes relatively more to overall ventilatory drive at high relative to low levels of hypercapnia.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-10956343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-10967346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-11457794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-11568155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-11641379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-12716866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-14517544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-15322066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-15322068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-15543803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-15579571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-15906312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-16105635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-16166236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-16455687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-16497844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-16690795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-16763105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-16794027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-16902062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-2120613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-2576930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-5505807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-6201783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-7713821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-8254528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-8304655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-8376301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-8843529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-9104854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-9451627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17336598-9593336
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1569-9048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
242-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17336598-Analysis of Variance,
pubmed-meshheading:17336598-Animals,
pubmed-meshheading:17336598-Blood Pressure,
pubmed-meshheading:17336598-Carbon Dioxide,
pubmed-meshheading:17336598-Cerebellar Nuclei,
pubmed-meshheading:17336598-Excitatory Amino Acid Agonists,
pubmed-meshheading:17336598-Female,
pubmed-meshheading:17336598-Goats,
pubmed-meshheading:17336598-Hydrogen,
pubmed-meshheading:17336598-Ibotenic Acid,
pubmed-meshheading:17336598-Male,
pubmed-meshheading:17336598-Pulmonary Gas Exchange,
pubmed-meshheading:17336598-Respiratory Mechanics,
pubmed-meshheading:17336598-Wakefulness
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pubmed:year |
2007
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pubmed:articleTitle |
The cerebellar fastigial nucleus contributes to CO2-H+ ventilatory sensitivity in awake goats.
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pubmed:affiliation |
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. paul.martino@wright.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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