| pubmed-article:17335190 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17335190 | lifeskim:mentions | umls-concept:C0206580 | lld:lifeskim |
| pubmed-article:17335190 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:17335190 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:17335190 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17335190 | lifeskim:mentions | umls-concept:C1553038 | lld:lifeskim |
| pubmed-article:17335190 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17335190 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17335190 | pubmed:dateCreated | 2007-3-29 | lld:pubmed |
| pubmed-article:17335190 | pubmed:abstractText | A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using structure--activity relationship information inferred from early hits, several compounds were synthesized, and compound 14 was identified as a potent, orally bioavailable first-in-class inhibitor of orthopoxvirus egress from infected cells. Compound 14 has shown comparable efficaciousness in three murine orthopoxvirus models and has entered Phase I clinical trials. | lld:pubmed |
| pubmed-article:17335190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17335190 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17335190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17335190 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17335190 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17335190 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:KernEarl RER | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:JordanRobertR | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:BurnsChristop... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:GuangYangY | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:HugginsJohn... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:BakerRobert... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:PevearDaniel... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:KeithKathy... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:CollettMarc... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:RhodesGerryG | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:TohanSanjeevS | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:HrubyDennisD | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:BaileyThomas... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:RippinSusan... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:OpsitnickEliz... | lld:pubmed |
| pubmed-article:17335190 | pubmed:author | pubmed-author:DaiDongchengD | lld:pubmed |
| pubmed-article:17335190 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17335190 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:17335190 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:17335190 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17335190 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17335190 | pubmed:pagination | 1442-4 | lld:pubmed |
| pubmed-article:17335190 | pubmed:dateRevised | 2009-1-28 | lld:pubmed |
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| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:meshHeading | pubmed-meshheading:17335190... | lld:pubmed |
| pubmed-article:17335190 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17335190 | pubmed:articleTitle | N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors. | lld:pubmed |
| pubmed-article:17335190 | pubmed:affiliation | ViroPharma Incorporated, 397 Eagleview Boulevard, Exton, Pennsylvania 19341, USA. tbailey@cephalon.com | lld:pubmed |
| pubmed-article:17335190 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17335190 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:17335190 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:17335190 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17335190 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17335190 | lld:pubmed |
