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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-3-29
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pubmed:abstractText |
A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using structure--activity relationship information inferred from early hits, several compounds were synthesized, and compound 14 was identified as a potent, orally bioavailable first-in-class inhibitor of orthopoxvirus egress from infected cells. Compound 14 has shown comparable efficaciousness in three murine orthopoxvirus models and has entered Phase I clinical trials.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:BaileyThomas RTR,
pubmed-author:BakerRobert ORO,
pubmed-author:BurnsChristopher JCJ,
pubmed-author:CollettMarc SMS,
pubmed-author:DaiDongchengD,
pubmed-author:GuangYangY,
pubmed-author:HrubyDennisD,
pubmed-author:HugginsJohn WJW,
pubmed-author:JordanRobertR,
pubmed-author:KeithKathy AKA,
pubmed-author:KernEarl RER,
pubmed-author:OpsitnickElizabethE,
pubmed-author:PevearDaniel CDC,
pubmed-author:RhodesGerryG,
pubmed-author:RippinSusan RSR,
pubmed-author:TohanSanjeevS
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1442-4
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pubmed:dateRevised |
2009-1-28
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pubmed:meshHeading |
pubmed-meshheading:17335190-Administration, Oral,
pubmed-meshheading:17335190-Animals,
pubmed-meshheading:17335190-Antiviral Agents,
pubmed-meshheading:17335190-Benzamides,
pubmed-meshheading:17335190-Biological Availability,
pubmed-meshheading:17335190-Cell Line,
pubmed-meshheading:17335190-Crystallography, X-Ray,
pubmed-meshheading:17335190-Humans,
pubmed-meshheading:17335190-Indoles,
pubmed-meshheading:17335190-Isoindoles,
pubmed-meshheading:17335190-Macaca fascicularis,
pubmed-meshheading:17335190-Mice,
pubmed-meshheading:17335190-Molecular Structure,
pubmed-meshheading:17335190-Orthopoxvirus,
pubmed-meshheading:17335190-Rats,
pubmed-meshheading:17335190-Stereoisomerism,
pubmed-meshheading:17335190-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors.
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pubmed:affiliation |
ViroPharma Incorporated, 397 Eagleview Boulevard, Exton, Pennsylvania 19341, USA. tbailey@cephalon.com
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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