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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0027651,
umls-concept:C0042196,
umls-concept:C0205263,
umls-concept:C0871261,
umls-concept:C1446409,
umls-concept:C1516213,
umls-concept:C1527249,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
12
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pubmed:dateCreated |
2007-10-2
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|
pubmed:abstractText |
Dendritic cells (DCs) are the most effective antigen-presenting cells. In the last decade, the use of DCs for immunotherapy of cancer patients has been vastly increased. High endocytic capacity together with a unique capability of initiating primary T-cell responses have made DCs the most potent candidates for this purpose. Although DC vaccination occasionally leads to tumor regression, clinical efficacy, and immunogenicity of DCs in clinical trials has not been yet clarified. The present study evaluated the safety and effectiveness of tumor-lysate loaded DC vaccines in advanced colorectal cancer (CRC) patients with carcinoembryonic antigen (CEA) positive tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0340-7004
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pubmed:author |
pubmed-author:BasagilaErnestoE,
pubmed-author:FarzanehFarzinF,
pubmed-author:GeorgeAndrew J TAJ,
pubmed-author:HabibNagyN,
pubmed-author:HarrisonPhillipP,
pubmed-author:JensenSteenS,
pubmed-author:JiaoLongL,
pubmed-author:KagahzianArashA,
pubmed-author:LechlerRobert IRI,
pubmed-author:LombardiGiovannaG,
pubmed-author:NichollsJoannaJ,
pubmed-author:StampGordonG,
pubmed-author:StaussHansH,
pubmed-author:TamirAyalaA,
pubmed-author:TatePaulP
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pubmed:issnType |
Print
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pubmed:volume |
56
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2003-16
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pubmed:meshHeading |
pubmed-meshheading:17333181-Aged,
pubmed-meshheading:17333181-Antigens, Neoplasm,
pubmed-meshheading:17333181-Cancer Vaccines,
pubmed-meshheading:17333181-Carcinoembryonic Antigen,
pubmed-meshheading:17333181-Colorectal Neoplasms,
pubmed-meshheading:17333181-Dendritic Cells,
pubmed-meshheading:17333181-Disease Progression,
pubmed-meshheading:17333181-Female,
pubmed-meshheading:17333181-Flow Cytometry,
pubmed-meshheading:17333181-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17333181-Humans,
pubmed-meshheading:17333181-Male,
pubmed-meshheading:17333181-Middle Aged,
pubmed-meshheading:17333181-T-Lymphocytes,
pubmed-meshheading:17333181-Treatment Outcome
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Induction of tumor-specific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic-antigen positive tumors.
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pubmed:affiliation |
Department of Immunology, Imperial College at Hammersmith Hospital, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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