| pubmed-article:17324055 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17324055 | lifeskim:mentions | umls-concept:C0001948 | lld:lifeskim |
| pubmed-article:17324055 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17324055 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:17324055 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17324055 | pubmed:dateCreated | 2007-2-27 | lld:pubmed |
| pubmed-article:17324055 | pubmed:abstractText | Alcoholism is a complex disorder influenced by interactions between genetic and environmental risk factors. This study examined the influence of isolate housing on ethanol intake in alcohol-preferring (P) and non-alcohol-preferring (NP) rats. Rats were isolate-housed or pair-housed for 8 weeks when between 45 and 96 days old. Ethanol drinking was assessed using a 24-hr preference test (10% ethanol vs. water) and 20-min limited access tests. A behavioral test battery was used to assess anxiety-like, depressive-like, acoustic startle, and motor behavior. Isolate housing increased home cage drinking in both lines and increased limited access drinking selectively in P rats. Isolation also reduced swim test immobility and prepulse inhibition in P rats and increased locomotor stereotypies in NP rats. Taken together, these data demonstrate that LinexEnvironment interactions influence the effects of isolation. Furthermore, isolation selectively increased ethanol intake in high drinking P rats. This effect was not correlated with changes in other behaviors. Selective enhancement of limited access ethanol drinking in P rats may represent a model whereby genetic liability to excessive drinking is enhanced by specific environmental exposures. | lld:pubmed |
| pubmed-article:17324055 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17324055 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17324055 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17324055 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17324055 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17324055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17324055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17324055 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17324055 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17324055 | pubmed:issn | 0735-7044 | lld:pubmed |
| pubmed-article:17324055 | pubmed:author | pubmed-author:EhlersCindy... | lld:pubmed |
| pubmed-article:17324055 | pubmed:author | pubmed-author:SlaweckiCraig... | lld:pubmed |
| pubmed-article:17324055 | pubmed:author | pubmed-author:WalkerBrendan... | lld:pubmed |
| pubmed-article:17324055 | pubmed:author | pubmed-author:PianJerry PJP | lld:pubmed |
| pubmed-article:17324055 | pubmed:author | pubmed-author:RothJennifer... | lld:pubmed |
| pubmed-article:17324055 | pubmed:copyrightInfo | Copyright (c) 2007 APA, all rights reserved. | lld:pubmed |
| pubmed-article:17324055 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17324055 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:17324055 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17324055 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17324055 | pubmed:pagination | 111-9 | lld:pubmed |
| pubmed-article:17324055 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:17324055 | pubmed:meshHeading | pubmed-meshheading:17324055... | lld:pubmed |
| pubmed-article:17324055 | pubmed:meshHeading | pubmed-meshheading:17324055... | lld:pubmed |
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| pubmed-article:17324055 | pubmed:meshHeading | pubmed-meshheading:17324055... | lld:pubmed |
| pubmed-article:17324055 | pubmed:meshHeading | pubmed-meshheading:17324055... | lld:pubmed |
| pubmed-article:17324055 | pubmed:meshHeading | pubmed-meshheading:17324055... | lld:pubmed |
| pubmed-article:17324055 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17324055 | pubmed:articleTitle | Increased alcohol drinking in isolate-housed alcohol-preferring rats. | lld:pubmed |
| pubmed-article:17324055 | pubmed:affiliation | Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA. cindye@scripps.edu | lld:pubmed |
| pubmed-article:17324055 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17324055 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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