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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-26
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pubmed:abstractText |
Cytokines and chemokines are proteins that play a critical role in the regulation of immunity and inflammation in patients with chronic Hepatitis C. The aim of our study was to correlate serum cytokines, chemokines and apoptosis in non-treated chronic hepatitis C patients with various degrees of inflammation and fibrosis. We studied 778 patients: 59 had low Knodell fibrosis score and low Knodell histological activity index; 372 had mild fibrosis and low histological activity index; 270 had moderate fibrosis and moderate histological activity index; and, 77 had high fibrosis and high histological activity index on their biopsy. Serum cytokines, chemokines and apoptosis were measured by enzyme-linked-immunosorbent-assay. Multivariate analysis was employed for statistical purposes. A positive correlation was seen between the degree of inflammation and tumor necrosis factor-alpha (TNF-alpha) levels (r = 0.92) in non-cirrhotic patients and between interleukin 2 in all patients (r = 0.85). Interleukin-8 increased significantly at higher histological activity indices and continued to increase in patients with cirrhosis. Transforming growth factor-beta (TGF-beta) levels increased significantly with the severity of fibrosis, but decreased in cirrhotics. In conclusion, cytokines, chemokines and apoptosis levels reflect the progression of inflammation and fibrosis in hepatitis C infected patients, but their signatures differ.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CCL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL5,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/NAP1L4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1931-5244
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pubmed:author |
pubmed-author:Ben-AriZivZ,
pubmed-author:BenhamouJean-PierreJP,
pubmed-author:BourliereMarcM,
pubmed-author:CameronRoss GRG,
pubmed-author:CohenLawrenceL,
pubmed-author:KatzGad GGG,
pubmed-author:MalkiewiczIzabella MIM,
pubmed-author:MarcellinPatrickP,
pubmed-author:MorganMaryM,
pubmed-author:NeumanManuela GMG,
pubmed-author:Schmilovitz-WeissHemdaH,
pubmed-author:TrepoCristhianC,
pubmed-author:VallaDominiqueD
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pubmed:issnType |
Print
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-36
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pubmed:dateRevised |
2008-6-2
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pubmed:meshHeading |
pubmed-meshheading:17320798-Antigens, CD95,
pubmed-meshheading:17320798-Apoptosis,
pubmed-meshheading:17320798-Biological Markers,
pubmed-meshheading:17320798-Biopsy,
pubmed-meshheading:17320798-Chemokine CCL2,
pubmed-meshheading:17320798-Chemokine CCL5,
pubmed-meshheading:17320798-Chemokines,
pubmed-meshheading:17320798-Cytokines,
pubmed-meshheading:17320798-Fibrosis,
pubmed-meshheading:17320798-Hepatitis C, Chronic,
pubmed-meshheading:17320798-Hepatocytes,
pubmed-meshheading:17320798-Humans,
pubmed-meshheading:17320798-Interleukin-12,
pubmed-meshheading:17320798-Interleukin-18,
pubmed-meshheading:17320798-Interleukin-2,
pubmed-meshheading:17320798-Interleukin-6,
pubmed-meshheading:17320798-Liver,
pubmed-meshheading:17320798-Microscopy, Electron,
pubmed-meshheading:17320798-Nuclear Proteins,
pubmed-meshheading:17320798-Severity of Illness Index,
pubmed-meshheading:17320798-Transforming Growth Factor beta,
pubmed-meshheading:17320798-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
Cytokine--chemokine and apoptotic signatures in patients with hepatitis C.
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pubmed:affiliation |
In Vitro Drug Safety and Biotechnology, MaRS Discovery Center, 101 College Street, Lab 351, Toronto, Ontario, M5G 1L7 Canada. manuela@sten.sunnybrook.utoronto.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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