Source:http://linkedlifedata.com/resource/pubmed/id/17318853
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-3-5
|
| pubmed:abstractText |
Liver transplantation can be a therapeutic option for individual patients with neuroendocrine tumors metastatic only to the liver. In this consecutive series of 15 patients (5 multivisceral and 10 orthotopic liver transplantations) with well-differentiated carcinoids, or endocrine pancreatic tumors, we allowed higher proliferation rate (Ki67 <10%), large tumor burden, and higher age than previous studies. Liver transplantation offered good relief of symptoms, long disease-free intervals, and potential cure in individual patients. The survival of grafts and patients compared well with transplantation for benign disease. The overall 5-year survival was 90%. The recurrence-free survival of both multivisceral and liver transplantation related to the time after transplantation (about 20% at 5 years) despite inclusion of patients with higher risk. In conclusion, the critical prognosticators for long-term outcome still remain to be defined. The experience with multivisceral transplantation for patients with endocrine tumors of the pancreatic head is still limited.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1527-6465
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| pubmed:author | |
| pubmed:copyrightInfo |
(c) 2007 AASLD.
|
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
327-33
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| pubmed:meshHeading |
pubmed-meshheading:17318853-Adult,
pubmed-meshheading:17318853-Duodenum,
pubmed-meshheading:17318853-Female,
pubmed-meshheading:17318853-Humans,
pubmed-meshheading:17318853-Immunosuppression,
pubmed-meshheading:17318853-Liver Neoplasms,
pubmed-meshheading:17318853-Liver Transplantation,
pubmed-meshheading:17318853-Male,
pubmed-meshheading:17318853-Middle Aged,
pubmed-meshheading:17318853-Neoplasm Recurrence, Local,
pubmed-meshheading:17318853-Neuroendocrine Tumors,
pubmed-meshheading:17318853-Organ Transplantation,
pubmed-meshheading:17318853-Pancreas Transplantation,
pubmed-meshheading:17318853-Pancreatic Neoplasms,
pubmed-meshheading:17318853-Prognosis,
pubmed-meshheading:17318853-Retrospective Studies,
pubmed-meshheading:17318853-Stomach,
pubmed-meshheading:17318853-Survival Rate,
pubmed-meshheading:17318853-Treatment Outcome
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors.
|
| pubmed:affiliation |
Sahlgrenska Transplant Institute, Sahlgrenska Academy, University of Göteborg, Göteborg, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|