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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003286,
umls-concept:C0003299,
umls-concept:C0004083,
umls-concept:C0008059,
umls-concept:C0014544,
umls-concept:C0376622,
umls-concept:C0814470,
umls-concept:C0814942,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1704939,
umls-concept:C1706817,
umls-concept:C1823242,
umls-concept:C1882417,
umls-concept:C2911692
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|
pubmed:issue |
1
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|
pubmed:dateCreated |
2007-2-19
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|
pubmed:abstractText |
P-glycoprotein 170 (P-gp) is a plausible biologic candidate for pharmacoresistance in epilepsy. The expression and efflux efficiency of P-gp is influenced by a polymorphism (C3435T) in the encoding gene (MDR1). The CC genotype at the MDR1 C3435T polymorphism was reported to be associated with the response to antiepileptic drug treatment. This study attempted to replicate this finding by examining the association of this genetic polymorphism with response to antiepileptic drug treatment in ethnic Han Chinese children with epilepsy.
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pubmed:language |
chi
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1008-8830
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-4
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pubmed:meshHeading |
pubmed-meshheading:17306068-Anticonvulsants,
pubmed-meshheading:17306068-Child,
pubmed-meshheading:17306068-China,
pubmed-meshheading:17306068-Epilepsy,
pubmed-meshheading:17306068-Gene Frequency,
pubmed-meshheading:17306068-Genotype,
pubmed-meshheading:17306068-Humans,
pubmed-meshheading:17306068-P-Glycoprotein,
pubmed-meshheading:17306068-Polymorphism, Genetic,
pubmed-meshheading:17306068-Polymorphism, Single Nucleotide
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
[Association of a polymorphism in MDR1 C3435T with response to antiepileptic drug treatment in ethic Han Chinese children with epilepsy].
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|
pubmed:affiliation |
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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pubmed:publicationType |
Journal Article,
English Abstract
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