Linked Life Data

17305554

Source:http://linkedlifedata.com/resource/pubmed/id/17305554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-2-19
pubmed:abstractText
Sleep is characterized by synchronized electrical activities of the thalamocortical network, which can be identified as the EEG oscillations during sleep. T-type calcium channels have been implicated in the occurrence of sleep waves, and burst firings in the thalamic neurons driven by these channels are known to be essential for modulation of sleep rhythms. Studies showed that alpha1(G) T-type calcium channel knockout mice had defects in sleep waves such as lack of delta oscillations (1-4 Hz) and alteration of sleep spindles (7-15 Hz), which are known to be modulated by T-currents in the thalamus. The mutation also affected the sleep-wake transition, thus resulting in decreased NREM sleep and increased sleep disturbance. These findings support the idea that alpha1(G) T-type calcium channels contribute to sleep waves as well as to behavioral state of sleep.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1871-5273
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-9
pubmed:dateRevised
2009-3-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
T-type calcium channels and thalamocortical rhythms in sleep: a perspective from studies of T-type calcium channel knockout mice.
pubmed:affiliation
Center for Neural Science, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-ku, Seoul.
pubmed:publicationType
Journal Article, Review