Linked Life Data

1730539

Source:http://linkedlifedata.com/resource/pubmed/id/1730539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-2-20
pubmed:abstractText
The localization of rat lens fatty acid cyclooxygenase (prostaglandin synthase) was studied using indirect immunofluorescent and indirect streptavidin-biotin immunoperoxidase staining techniques. Both methods employed monoclonal and polyclonal antibodies directed against fatty acid cyclooxygenase, the key enzyme in the conversion of arachidonic acid to prostaglandins. The immunocytochemical studies demonstrate that (1) fatty acid cyclooxygenase is present in the rat lens epithelial cell layer; (2) the enzyme appears predominantly in the cytoplasm; (3) there is an apparent higher concentration of the enzyme in the region designated as germinative and transitional zones, and meridional rows; and (4) the enzyme appears to be absent in the lens capsule and in the nucleus of the lens. The presence of the cyclooxygenase enzyme in the lens epithelium, especially the relative intense staining in the epithelial mitogenic region, suggests that oxygenation of polyunsaturated fatty acids by the fatty acid cyclooxygenase may have an important role in cellular differentiation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
178-83
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Immunocytochemical localization of cyclooxygenase in the rat lens.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.